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CCK-expressing neurons in the NTS are directly activated by CCK-sensitive C-type vagal afferents.
Am J Physiol Regul Integr Comp Physiol
January 2025
Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington, United States.
Vagal sensory afferents carrying information from the gastrointestinal tract (GI) terminate in the nucleus of the solitary tract (NTS). Different subpopulations of NTS neurons then relay this information throughout the brain. Cholecystokinin (CCK) is a satiety peptide that activates vagal afferents in the GI.
View Article and Find Full Text PDFPlasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth.
Proc Natl Acad Sci U S A
August 2023
Team Brain Development and Plasticity, Institut de Biologie de l'ENS, École Normale Supérieure, CNRS, INSERM, PSL Research University, 75005 Paris, France.
Sensory inputs are conveyed to distinct primary areas of the neocortex through specific thalamocortical axons (TCA). While TCA have the ability to reorient postnatally to rescue embryonic mistargeting and target proper modality-specific areas, how this remarkable adaptive process is regulated remains largely unknown. Here, using a mutant mouse model with a shifted TCA trajectory during embryogenesis, we demonstrated that TCA rewiring occurs during a short postnatal time window, preceded by a prenatal apoptosis of thalamic neurons-two processes that together lead to the formation of properly innervated albeit reduced primary sensory areas.
View Article and Find Full Text PDF[Olfactory receptors expressed in various non-olfactory tissues.].
Clin Calcium
May 2019
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Olfactory receptor(OR)genes constitute the largest gene family in mammals. Some of them have been shown to be expressed not only in the olfactory system, but also in various non-olfactory tissues. So far, the roles of such ectopically expressed ORs have been suggested mainly by in vitro experiments using cultured cells or tissues.
View Article and Find Full Text PDFEnterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
Cell
June 2017
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:
Dietary, microbial, and inflammatory factors modulate the gut-brain axis and influence physiological processes ranging from metabolism to cognition. The gut epithelium is a principal site for detecting such agents, but precisely how it communicates with neural elements is poorly understood. Serotonergic enterochromaffin (EC) cells are proposed to fulfill this role by acting as chemosensors, but understanding how these rare and unique cell types transduce chemosensory information to the nervous system has been hampered by their paucity and inaccessibility to single-cell measurements.
View Article and Find Full Text PDFInnocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.
J Neurophysiol
January 2017
Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California; and.
Unlabelled: Itch is often triggered by warming the skin in patients with itchy dermatitis, but the underlying mechanism is largely unknown. We presently investigated if warming the skin enhances histamine- or serotonin (5-HT)-evoked itch behavior or responses of sensory dorsal root ganglion (DRG) cells, and if responses of superficial dorsal horn neurons to innocuous warming are enhanced by these pruritogens. In a temperature-controlled environmental chamber, mice exhibited greater scratching following intradermal injection of 5-HT, but not histamine, SLIGRL, or BAM8-22, when the skin surface temperature was above 36°C.
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