Following transurethral resection of the tumour, 58 patients with histologically verified transitional cell carcinoma were subjected to local instillation treatment and oral vitamin A therapy. The instillation were carried out once a week over a 6-week period; cystoscopy with biopsy were carried out at 3-month intervals over an average period of 2.7 years. The vitamin A treatment appears to have no positive effect on persistent growth and on tendency to recurrence.
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Syst Rev
January 2025
Department of Medicine, Division of Infectious Diseases, Duke University, 148 Hanes House, 315 Trent Dr, Durham, NC, 27710, USA.
Background: Although intravesical Bacillus Calmette-Guerin (BCG) immunotherapy usually exhibits a favorable safety profile, it can lead to the development of BCG infections, both localized and disseminated. Understanding of BCG infections following intravesical BCG immunotherapy is limited because of the lack of consensus definitions of BCG infections and limited post-instillation follow-up. We aim to perform a systematic review of the literature of BCG infections following intravesical BCG immunotherapy to elucidate the epidemiology, risk factors, and outcomes of BCG infections.
View Article and Find Full Text PDFOpen Res Eur
January 2025
Institute of Ethnology and Folklore Studies with Ethnographic Museum, Bulgarian Academy of Sciences, Sofia, 1000, Bulgaria.
Previous research shows the importance of building up self-help structures in a transnational perspective for the inclusion of migrant women who are fleeing their home countries because of war, violence, or different forms of vulnerability. The mobilization of self-help organizations through the intersection of transnationalism and gender is, in fact, a useful direction for a practice-oriented pedagogy directed both towards (1) the most vulnerable groups of women, or (2) those already empowered either as community leaders or network facilitators, other migrants and the whole native population. For this paper, we compare two video-interviews of refugee women collected in Bulgaria and Italy, which are important receiving countries either at the South-Eastern or Southern external border of the European Union.
View Article and Find Full Text PDFRespir Res
January 2025
UR3738 CICLY Team Inflammation and Immunity of the Respiratory Epithelium, Claude Bernard University, Lyon 1, Pierre-Bénite, France.
Background: In patients with chronic obstructive pulmonary disease (COPD), a sensitization to A. fumigatus has been related to a decline in lung function, but the role of fungal agents in the disease pathogenesis remains unclear. The main purpose of the present study was to investigate whether cell inflammation could worsen after exposure to A.
View Article and Find Full Text PDFCancer Cell
January 2025
Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Centre for Cancer Evolution, Bart's Cancer Institute, Queen Mary University London, London EC1M 6AU, UK. Electronic address:
Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identifying and expanding this patient population remains a pressing clinical need. Here, we report that an interferon-high immunophenotype locally enriched in cytotoxic lymphocytes and antigen-presenting macrophages is required for response.
View Article and Find Full Text PDFInt Urol Nephrol
January 2025
Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Purpose: Intravesical (i) immunotherapy with Bacillus Calmette-Guérin (BCG) is the recommended treatment for patients with intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC) after complete tumor resection. Discontinuation or suspension of this therapy is often due to local side effects. Aim of the study was to evaluate the efficacy and safety of sequential intravesical instillations of combined hyaluronic acid (HA) and chondroitin sulfate (CS) in reducing local BCG toxicity and urinary symptoms.
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