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Comparison of the efficacy of curcumin and its nano formulation on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in Wistar rats.
Heliyon
December 2024
Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Background And Objective: Insulin resistance is a primary feature of type 2 diabetes. This study compared the effects of curcumin and its nanoformulation on insulin resistance, fasting blood sugar, liver function, GLUT4, lipid profile, and oxidative stress in the liver and pancreas in a diabetic model.
Methods: Thirty male Wistar rats were divided into five groups: a control group, a diabetic group, a diabetic group treated with metformin (40 mg/kg), a diabetic group treated with curcumin (100 mg/kg), and a diabetic group treated with curcumin NPs (100 mg/kg).
Ultrasound-controllable dexamethasone-loaded nanobubbles for highly effective rheumatoid arthritis therapy.
J Mater Chem B
January 2025
Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China.
Rheumatoid arthritis (RA) is an autoimmune disease that seriously threatens human health and affects the quality of life of patients. At present, pharmacotherapy is still the mainstream treatment for RA, but most methods have shortcomings, such as poor drug targeting, a low effective drug dosage at the inflammatory site, and high systemic toxicity. The combined application of drug-loaded nanobubbles and ultrasound technology provides a new technique for the treatment of RA.
View Article and Find Full Text PDFA Case of X-Linked Agammaglobulinemia and COVID-19 in a Japanese Infant.
J Nippon Med Sch
January 2025
Department of Pediatrics, Nippon Medical School.
An infant was diagnosed as having X-linked agammaglobulinemia (XLA) at age 3 months and was receiving immunoglobulin replacement therapy. He developed SARS-CoV-2 infection at age 7 months and was treated with intravenous immunoglobulin, remdesivir, and dexamethasone. His respiratory symptoms improved quickly, and the infection resolved.
View Article and Find Full Text PDFNanoemulsion-based pseudopolyrotaxane hydrogel for enhanced corneal bioavailability and treatment of corneal inflammation.
J Control Release
January 2025
School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China. Electronic address:
Corneal inflammation, a condition that can potentially lead to blindness, is often treated with topical eye drops. However, the limited ocular drug bioavailability of the eye drops necessitates frequent dosing. Herein, a nanoemulsion-based pseudopolyrotaxane hydrogel was fabricated to improve corneal bioavailability and thereby suppress inflammation.
View Article and Find Full Text PDFAmaryllidaceae alkaloids with nitric oxide inhibitory activity from the leaves of Crinum asiaticum L. var. asiaticum.
Phytochemistry
January 2025
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Forty-two Amaryllidaceae alkaloids, including eleven previously undescribed alkaloids, crinasiaticines C-M, and three undescribed naturally occurring alkaloids, (+)-dihydroepivittatine, (+)-dihydrovittatine and (+)-dihydrohamayne, were isolated from the leaves of Crinum asiaticum L. var. asiaticum.
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