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The Cholesterol Paradox in Long-Livers from a Sardinia Longevity Hot Spot (Blue Zone).
Nutrients
February 2025
Dipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Clinica Medica, Viale San Pietro 8, 07100 Sassari, Italy.
: Hypercholesterolemia is commonly viewed as a risk factor for coronary heart disease; however, several studies have reported an inverse relationship between cholesterol levels and cardiovascular mortality, particularly in older adults. This "cholesterol paradox" challenges the conventional understanding of lipid metabolism. Despite often being dismissed as a result of reverse causality, the precise causes of this paradox remain poorly understood.
View Article and Find Full Text PDFZNF667 alleviates the inflammatory damage in intervertebral disc degeneration via inhibiting NF-κB signaling pathway.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Spine Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objectives: With the aging population, the incidence of intervertebral disc degeneration (IDD) is increasing every year. The pathogenesis of IDD is complex, and there are currently no effective treatment options. This study aims to investigate the specific function and underlying mechanism of zinc finger protein 667 (ZNF667) in the inflammatory damage of nucleus pulposus cells in IDD.
View Article and Find Full Text PDFThe power of interspecific sociality: how humans provide social buffering for horses.
Anim Cogn
March 2025
Department of Environmental, Biological and Pharmaceutical Sciences & Technologies, University of Campania Luigi Vanvitelli, 81100, Caserta, Italy.
In this study, we assessed the interspecific "social buffering effect" of humans on horses, exploring how human presence influences stress responses in horses in an unfamiliar environment using the "isolation paradigm." We examined nine Haflinger horses under two counterbalanced conditions: with a passive human stranger (social condition) or alone (isolation condition). Stress responses were assessed through cortisol measurements, heart rate monitoring, and behavioral observations.
View Article and Find Full Text PDFProbiotics ameliorates hypothalamic amenorrhea in a rat model of PCOS.
Metab Brain Dis
March 2025
Cardio/Endo-Metabolic and Epigenetics Research Unit, Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, 360101, Nigeria.
Background: Polycystic ovary syndrome (PCOS) is a common endocrinometabolic disorder affecting women of reproductive age, characterized by hormonal imbalances, irregular menstrual cycles, and often, infertility. Hypothalamic amenorrhea, a condition marked by the cessation of menstruation due to disruptions in the hypothalamic-pituitary-gonadal axis, is a frequent manifestation in PCOS. Probiotics, beneficial microorganisms known for improving metabolic health, have shown promise in restoring hormonal balance and enhancing fertility.
View Article and Find Full Text PDFMechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 Macrophages.
Integr Cancer Ther
March 2025
Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chemoresistance is still an important factor affecting the efficacy of treatment in colorectal cancer (CRC) patients. Hypoxia is related to poor prognosis and treatment resistance in cancer. Relevant studies have shown that a hypoxic microenvironment can promote the polarization of M2 macrophages and thus promote tumor development.
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