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A child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition?
Ital J Pediatr
January 2025
Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, Pavia, 27100, Italy.
Background: Chronic Nonbacterial Osteomyelitis (CNO) is a rare auto-inflammatory disease that mainly affects children, and manifests with single or multiple painful bone lesions. Due to the lack of specific laboratory markers, CNO diagnosis is a matter of exclusion from different conditions, first and foremost bacterial osteomyelitis and malignancies. Whole Body Magnetic Resonance (WBMR) and bone biopsy are the gold standard for the diagnosis.
View Article and Find Full Text PDFPesticide transformation products: a potential new source of interest for drinking water.
Environ Sci Pollut Res Int
January 2025
ANSES, Nancy Laboratory for Hydrology, Water Chemistry Department, 40 Rue Lionnois, 54000, Nancy, France.
Pesticide transformation products (TPs) are frequently quantified in aquatic systems, including surface and groundwater. They often present higher polarity than parent compounds, are less volatile and less biodegradable and are therefore more mobile and persistent. These properties make them compounds of main interest in water resources and drinking water.
View Article and Find Full Text PDF[New approaches for pathology teaching in undergraduate medical studies, the University Paris-Saclay experience].
Ann Pathol
January 2025
Service d'anatomie et cytologie pathologiques, hôpital Bicêtre, AP-HP, université Paris-Saclay, Le Kremlin-Bicêtre, France; Faculté de médecine, université Paris-Saclay, Le Kremlin-Bicêtre, France.
Introduction: Teaching pathology is an essential and early part of the medical curriculum. It is classically theoretical, often accompanied by tutorials. Access to pathology internships for students is not always possible.
View Article and Find Full Text PDFCSF-Venous Fistulas Arising Intraosseously within Bone Remodeled by Meningeal Diverticula.
AJNR Am J Neuroradiol
January 2025
Department of Radiology (M.D.M.), Permanente Medical Group, Kaiser Permanente Medical Center Santa Clara, Santa Clara, California.
CSF-venous fistulas (CVFs) are a common and increasingly recognized type of spinal CSF leak. Most of these fistulas occur in the setting of spontaneous intracranial hypotension, though nonspontaneous cases have been described as well. In most instances, CVFs arise from the dome or neck of nerve root sleeve diverticula (also called meningeal diverticula).
View Article and Find Full Text PDFThe absorption, distribution, metabolism and elimination characteristics of small interfering RNA therapeutics and the opportunity to predict disposition in pregnant women.
Drug Metab Dispos
January 2025
ReNAgade Therapeutics Management Inc, Cambridge, Massachusetts. Electronic address:
Small interfering RNA (siRNA) therapeutics represent an emerging class of pharmacotherapy with the potential to address previously hard-to-treat diseases. Currently approved siRNA therapeutics include lipid nanoparticle-encapsulated siRNA and tri-N-acetylated galactosamine-conjugated siRNA. These siRNA therapeutics exhibit distinct pharmacokinetic characteristics and unique absorption, distribution, metabolism, and elimination (ADME) properties.
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