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Dosing and route of administration of clindamycin given in combination with rifampicin.
Clin Microbiol Infect
January 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France; Unité Fonctionelle de Pharmacologie, GHU Paris Seine Saint-Denis, Assistance Publique-Hôpitaux de Paris (APHP), Université Sorbonne Paris Nord, Bondy, France.
Objectives: The aim of the present study was to develop a PK interaction model of intravenous (IV) and oral clindamycin when combined with rifampicin, and to determine whether appropriate clindamycin concentrations could be achieved for different doses and administration routes (oral, intermittent and continuous infusion) of clindamycin.
Methods: Five hundred and eighteen plasma samples were prospectively obtained from 124 patients treated for bone and joint infections. Population PK analysis was performed using Monolix software.
Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis.
bioRxiv
October 2024
Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.
Tuberculosis (TB) is historically the world's deadliest infectious disease. New TB drugs that can avoid pre-existing resistance are desperately needed. The β-lactams are the oldest and most widely used class of antibiotics to treat bacterial infections but, for a variety of reasons, they were largely ignored until recently as a potential treatment option for TB.
View Article and Find Full Text PDFMedical Therapy Alone for Ommaya Reservoir-Associated Bacterial Meningitis: When It Works and When It Fails.
Neurosurgery
January 2025
Department of Neurosurgery, Hershey Medical Center, Hershey, Pennsylvania, USA.
Background And Objectives: Administration of intraventricular chemotherapy through Ommaya reservoir is indicated for certain forms of leptomeningeal disease. However, ventricular reservoirs carry a substantial risk of infection. The conventional approach to managing reservoir-associated infections involves removal of the reservoir and systemic antibiotic therapy, but this strategy necessitates additional procedures to remove and subsequently replace the device.
View Article and Find Full Text PDFEuropean S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment.
J Eur Acad Dermatol Venereol
December 2024
European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.
Introduction: This second part of the S2k guidelines is an update of the 2015 S1 European guidelines.
Objective: These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS).
Methods: The chapters have been selected after a Delphi procedure among the experts/authors.
Clinical Presentation and Management of Pulmonary Infection Caused by Mycobacterium paraffinicum.
Cureus
October 2024
Internal Medicine, Stockport NHS Foundation Trust, Manchester, GBR.
Article Synopsis
- * Initial diagnosis suggested pulmonary tuberculosis due to the patient's symptoms; however, lab tests identified an NTM infection after ruling out other common pathogens.
- * The patient underwent successful treatment with a combination of targeted antibiotics and demonstrated significant clinical recovery over 12 months, highlighting the need to consider NTM infections in similar cases when TB treatment fails.
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