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A single-domain antibody targeting factor XII inhibits both thrombosis and inflammation.
Nat Commun
September 2024
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- Factor XII (FXII) is crucial for activating the body's intrinsic coagulation pathway and has a previously unclear role in inflammation.
- Treating male mice with a novel antibody (Nb-Fc) that targets FXII significantly reduced arterial thrombosis without disrupting normal blood clotting.
- The study shows that inhibiting FXII can lower inflammation-related symptoms and complications during procedures like extracorporeal membrane oxygenation (ECMO), indicating its potential as a therapeutic target for thrombo-inflammatory diseases.
Predictors of bleeding and thrombotic events among patients admitted to the hospital with COVID-19 and elevated D-dimer: insights from the ACTION randomized clinical trial.
J Thromb Thrombolysis
August 2024
Brazilian Clinical Research Institute, São Paulo, Brazil.
Article Synopsis
- Therapeutic anticoagulation in COVID-19 patients shows mixed outcomes, complicating the selection of suitable patients due to balancing thrombotic and bleeding risks.
- A post-hoc analysis of the ACTION trial examined factors linked to bleeding and thrombotic events, using logistic regression to identify significant variables.
- Key findings included that non-invasive respiratory support related to thrombotic risks, invasive ventilation increased risks for both outcomes, and factors like creatinine levels and a history of coronary disease were important in determining thrombotic risk.
Elevated plasma FXII is associated with disease activity in ANCA-associated vasculitis: A Retrospective Cross-Sectional Study in Western China.
Int Immunopharmacol
December 2023
Department of Nephrology, Sichuan Provincial People's Hospital, Sichuan Clinical Research Center for Kidney Diseases, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China. Electronic address:
Article Synopsis
- - The study focused on analyzing plasma FXII levels in 127 patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to see if they indicate disease activity compared to healthy individuals and those in remission.
- - Findings showed that higher plasma FXII levels were linked to various markers of kidney damage and inflammation, making it a more effective indicator of AAV activity than traditional tests.
- - The research concluded that elevated plasma FXII levels could be reliable biomarkers for assessing the clinical and histological severity of AAV, particularly in kidney tissues.
Trends in perioperative practices of high-risk surgical patients over a 10-year interval.
PLoS One
September 2023
Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo-SP, Brasil.
Article Synopsis
- In Brazil, a study revealed a significant reduction in complications and death rates among high-risk surgical patients admitted to ICUs over a 10-year period, comparing cohorts from 2008 and 2018.
- Analysis of 704 patients showed that the 2008 cohort had more postoperative infections and complications, while improvements in patient management were noted in the 2018 cohort.
- Key factors linked to increased hospital mortality included high fluid balance, elevated creatinine levels, and intraoperative blood transfusions, whereas higher mean arterial pressure was associated with decreased mortality risk.
Hemostatic Effects of Bio-Zeolite Gauze and QuikClot Combat Gauze on Major Bleeding in Rabbits Acutely Exposed to High Altitude.
Prehosp Emerg Care
September 2023
Key Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, China.
Hemostatic gauze application is an effective way to control major bleeding, which is the most common cause of death in trauma in both civilian and military settings. Coagulation derangement after acute exposure to high altitude might alter the effects of hemostatic gauzes. The present study aimed to observe the hemostatic effects of bio-zeolite gauze (BZG) and QuikClot Combat Gauze® (QCG) on major bleeding in rabbits acutely exposed to high altitude.
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