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Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma.
Physiol Res
September 2017
Institute of Endocrinology, Prague, Czech Republic.
This work discusses the clinical performance of chromogranin A, free metanephrine and normetanephrine determination in plasma using a radioimmunoanalytical methods for the diagnosis of pheochromocytoma and paraganglioma. Blood samples were collected from 55 patients (46 pheochromocytomas, 9 paragangliomas). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery.
View Article and Find Full Text PDFKinetics and equilibrium in insulin radioimmunoassay.
J Immunoassay Immunochem
May 2003
Department of Physical Chemistry, Faculty of Pharmacy, University of Valencia, Avda. Vicent Andrés Estellés s/n, 46110 Burjassot, Valencia, Spain.
The kinetics of insulin reaction has been studied with its specific antibody immobilized on the inner wall of the reaction tube; the radioimmunoanalytical determination of such a substance is based on the reaction. Independent variables were labelled and unlabelled insulin concentrations, temperature, viscosity, and the medium's ionic strength. Biexponential kinetics was found to be dependent on the concentrations fitted to the models discussed in the paper.
View Article and Find Full Text PDFThere are suggestive data with indicate the link of testosterone levels with specific cognitive abilities in humans. As soon as during intrauterine development, testosterone is supposed to influence to organization of fetal specific brain structures. This influence is permanent and it is reflected in cognitive abilities during prepubetal period.
View Article and Find Full Text PDF[Type I and III procollagen in patients with abdominal aorta aneurysms].
Cas Lek Cesk
March 1999
Chirurgická klinika FN, Plzen.
Background: Collagen and elastin are the basic building stones of the aortal wall. During the process of development of an aneurysm of the abdominal aorta (AAA) degradation and remodelling of elastin and collagen in the intercellular matrix of its wall occurs. The two main types of collagen in the aorta are collagens type I and III.
View Article and Find Full Text PDF[Anti-insulin antibodies and insulin resistance].
Vnitr Lek
February 1995
3. interní klinika, 1. LF UK, Praha.
The submitted review deals with the phenomenon of immunological insulin resistance in insulin dependent diabetics which develops as a result of the presence of circulating anti-insulin antibodies as a response of the organism to administered insulin. This phenomenon is a liminal situation when anti-insulin antibodies exceed as to their concentration and affinity a certain arbitrary limit and the increasingly impaired pharmacokinetics of insulin cause a clinically manifest metabolic decompensation of the disease with the necessity of large daily doses of exogenous insulin. The authors discuss factors ensuing from the type of the administered insulin preparation, as well as the biological predisposition of the patient which potentiates the production of anti-insulin antibodies.
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