The stimulation of luminescence and cell aldehyde factor during the growth of one-aldehyde-dependent mutant in the condition medium by other aldehyde-dependent mutants was studied. It was shown that the aldehyde factor is synthesized in five successive steps, thus suggesting the participation of five enzymes in aldehyde factor synthesis. The metabolite accumulation in the condition medium increases both the level of the aldehyde factor and that of luciferase. It is assumed that some precursors of the aldehyde factor are involved in the regulation of the luminescence development.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cinnamaldehyde impacts key cellular signaling pathways for induction of programmed cell death in high-grade and low-grade human glioma cells.
BMC Res Notes
January 2025
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA.
Objective: Primary tumors of the brain and a large percent of malignant brain tumors are gliomas. Gliomas comprise high-grade gliomas like glioblastoma multiforme (GBMs), many of which have mutation in the tumor suppressor p53 gene and low-grade gliomas (LGGs). LGGs can progress to GBMs due to various factors.
View Article and Find Full Text PDFThe Role of Inflammation, Oxidative Stress, Neuronal Damage, and Endothelial Dysfunction in the Neuropathology of Cognitive Complications in Diabetes: A Moderation and Mediation Analysis.
Brain Behav
January 2025
Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Objective: Cognitive impairment is increasingly recognized as a complication of diabetes, yet the underlying pathology remains unclear. This study aims to investigate the roles of inflammation, oxidative stress, endothelial dysfunction, and neuronal damage in the neuropathology underlying diabetes related cognitive impairment.
Methods: This study assessed 183 participants (54 prediabetes, 71 Type 2 diabetes mellitus [T2DM], and 58 controls) for cognitive performance using the Montreal Cognitive Assessment (MoCA).
High-throughput screening of acetals/ketals in edible essences via GC-Orbitrap-MS and their formation rates at room temperature.
Food Chem
January 2025
Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan 450001, China.
Flavors contain active aldehydes and ketones that react with glycerol and propylene glycol to form acetals and ketals. The identification of acetals and ketals is challenging due to the incomplete information in mass spectral libraries. This study examines the reaction kinetics of 36 aldehydes and ketones with propylene glycol and glycerol, and establishes a high sensitivity and throughput screening method for 185 acetals and ketals using GC-Orbitrap-MS.
View Article and Find Full Text PDFExploring the synergistic effects of soil nutrients, rhizosphere fungi, and endophytic fungi on the shaping of root metabolites in Angelica sinensis (Oliv.) Diels.
Fungal Biol
February 2025
School of Agricultural and Biological Engineering, Longdong University, Qingyang, 745000, China; Gansu Key Laboratory of Protection and Utilization for Biological Resources and Ecological Restoration, Longdong University, Qingyang, 745000, China.
The root of Angelica sinensis (Oliv.) Diels (Ang) is a bulk Chinese herbal medicine, and the microecological regulation is a sustainable means to enhance its quality. In this study, Angs at five bases (LZ, XZ, QS, PM, MZC) in Minxian County, Gansu Province were taken as the research objects.
View Article and Find Full Text PDFRegulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis.
Nat Commun
January 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
Oxidative stress plays a critical role in postmenopausal osteoporosis, yet its impact on osteoblasts remains underexplored, limiting therapeutic advances. Our study identifies phospholipid peroxidation in osteoblasts as a key feature of postmenopausal osteoporosis. Estrogen regulates the transcription of glutathione peroxidase 4 (GPX4), an enzyme crucial for reducing phospholipid peroxides in osteoblasts.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!