Electron microscopic study of cardiomyocytes of Wistar rats using an experimental model of myocardial insufficiency induced by injection of rubomycin was carried out. A number of submicroscopic changes occurring in cardiomyocytes when protein synthesis was disturbed (autophagy and sequestration of glycogen, focal cytoplasmic degradation, increased number of secondary lysosomes) were shown to be the structural manifestations of inhibition of RNA synthesis in the nucleus. Alongside with involutional processes, the pathological changes of basic organelles consisting of thinning of myofibrils and decrease of mitochondrial membrane stability were revealed. At the stage of renewal of synthetic processes the dysbalance between intracellular regeneration and abnormalities of new formation of myofibrils was noted. All the observed ultrastructural changes form a morphological basis of development of contractile myocardial plastic insufficiency.
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