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Longitudinal analysis of anthropometric measures over 5 years in patients with Friedreich ataxia in the EFACTS natural history study.
Eur J Neurol
January 2025
Department of Neurology, RWTH Aachen University, Aachen, Germany.
Background: Friedreich ataxia is a rare neurodegenerative disorder caused by frataxin deficiency. Both underweight and overweight occur in mitochondrial disorders, each with adverse health outcomes. We investigated the longitudinal evolution of anthropometric abnormalities in Friedreich ataxia and the hypothesis that both weight loss and weight gain are associated with faster disease progression.
View Article and Find Full Text PDFThe role of astrocytes in Alzheimer's disease: a bibliometric analysis.
Front Aging Neurosci
November 2024
Department of Laboratory Medicine, The Second People's Hospital of Guizhou Province, Guiyang, China.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline and memory loss. Recent research underscores the crucial role of astrocytes in AD. This study reviews research trends and contributions on astrocytes in AD from 2000 to 2024, shedding light on the evolving research landscape.
View Article and Find Full Text PDFBion/Winnicott encounter: absence, failure and the negative in the work of Bion and Winnicott.
Am J Psychoanal
December 2024
, Brookline, MA 02446, USA.
After the death of Freud, a major thrust of the expansion of psychoanalytic theory involved the increasing recognition that the actuality of the emotional functioning of the object,-the primary objects in the infant's development, the analyst as object in the treatment process-were crucial determinants of developmental and therapeutic outcome. This recognition has been the driving force behind the evolution of various iterations of the role of interaction, inter-affectivity and intersubjectivity in two-person theories of psychic development and therapeutic action. This paper attempts to briefly trace in the work of Bion, Winnicott, Green and the Paris Psychosomatic School not only the effects of traumatic occurrences, but of their negative-i.
View Article and Find Full Text PDFPsycho-Somatic Evolution of Patients with Multiple Traumatic Injuries.
Clin Pract
November 2024
Clinical-Medical Department, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, 47 Str. Domnească, 800201 Galati, Romania.
Background And Objective: In this study, we aimed to identify the factors that could impact the Stress-Related Growth Scale (SRGS) questionnaire administered to patients.
Materials And Methods: Participants were asked to complete a written SRGS questionnaire (a translated and approved version in Romania) at varying time intervals relative to the traumatic event. The questionnaire was developed in accordance with legal regulations of the World Health Organization and the European Union for research involving human subjects for medical purposes.
Neuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.
J Neurol Neurosurg Psychiatry
September 2024
Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric University Hospital, Zurich, Switzerland
Background And Objectives: Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.
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