In a follow-up health control of 69-year-old persons in Stockholm, 589 were examined psychiatrically. Of these, 462 persons had responded affirmatively to symptoms indicating a depressive syndrome. Neurotic disorders were judged to be present in 258 persons, sleeping disturbances in 81, other types of psychiatric disorders in 10 whereas 113 persons were judged to be without psychiatric symptoms. In addition, 127 persons constituting a control group were examined. Of these 89 were judged to be without psychiatric symptoms while 38 had some form of psychiatric disturbance. The 258 persons in the group 'neurotic disorders' and the 81 in the group 'sleeping disturbances' were compared with the 89 persons in the control group judged to be without psychiatric symptoms. The comparisons included a number of variables of medical and social interest. Significantly more persons in the groups with neurotic disorders orders and sleeping disturbances than in the group without psychiatric symptoms reported impaired mobility and high blood pressure, worried about their health, took pain-killing pills daily and had financial worries. Median income was lower for the group with financial worries than for the groups without. Women in the group 'early onset neurosis' claimed significantly more often than women in the group without psychiatric symptoms that a member of their immediate family had suffered from mental disorder. The group 'late onset neurosis' did not differ in this respect from the group without psychiatric symptoms. Bereavement was significantly more often claimed by women in the group 'late onset neurosis' versus women in the group 'early onset neurosis'. Information on social group and level of education indicated that it was the better situated and better educated who took part in the health check-up.
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http://dx.doi.org/10.1111/j.1600-0447.1983.tb09722.x | DOI Listing |
J ECT
November 2024
Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA.
Electroconvulsive therapy (ECT) is underused, logistically challenging for those who are justice-involved, and laced with ethical problems for those on death row. Herein we describe a case of a man without history of long-standing psychiatric illness who, after more than 15 years on death row, was hospitalized for altered mental status. After medical stabilization, the altered mental status persisted.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China.
Fragile X syndrome (FXS) is an inherited neurodevelopmental disorder characterized by a range of clinical manifestations with no effective treatment strategy to date. Here, transplantation of GABAergic precursor cells from the medial ganglionic eminence (MGE) is demonstrated to significantly improve cognitive performance in Fmr1 knockout (KO) mice. Within the hippocampus of Fmr1-KO mice, MGE-derived cells from wild-type donor mice survive, migrate, differentiate into functionally mature interneurons, and form inhibitory synaptic connections with host pyramidal neurons.
View Article and Find Full Text PDFPrim Care Companion CNS Disord
January 2025
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.
View Article and Find Full Text PDFPLoS One
January 2025
Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.
Background: Posttraumatic stress disorder (PTSD) affects 3.9% of the general population. While massed cognitive processing therapy (CPT) has demonstrated efficacy in treating chronic PTSD, a substantial proportion of patients still continue to meet PTSD criteria after treatment, highlighting the need for novel therapeutic approaches.
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