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| http://dx.doi.org/10.1136/bmj.2.6134.433 | DOI Listing |
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From pro-re-nata to fixed-interval regimen: evolving real-world treatment paradigms in anti-VEGF therapy for neovascular AMD.
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Department of Medicine-Ophthalmology, University of Udine, Udine, Italy.
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State-of-the-Art Personalized Therapy Approaches for Chronic Non-Specific Low Back Pain: Understanding the Mechanisms and Drivers.
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Chronic non-specific low back pain (CNSLBP) is a debilitating condition that affects millions of people worldwide, significantly impacting quality of life and imposing a substantial socioeconomic burden. Traditional treatment approaches often rely on a one-size-fits-all strategy, failing to account for individual variations in pathophysiological mechanisms, drivers, and the principles of personalized medicine. Furthermore, an overemphasis on biomechanical findings from imaging may lead to ineffective interventions and unnecessary surgical procedures, obscuring other important factors that contribute to pain perception.
View Article and Find Full Text PDFEffectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol for a factorial randomised controlled trial.
BMJ Open
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Southern Medical University Institute for Global Health, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, China
Introduction: Traditional Chinese medicine (TCM) is commonly used alongside Western medicine for stroke management in China. However, there is significant variation in TCM practice, and the utilisation of evidence-based clinical practice guidelines is inadequate. This study aims to evaluate the effectiveness of three popular frameworks-Consolidated Framework for Implementation Research (CFIR), Theoretical Domains Framework (TDF) and Normalization Process Theory (NPT)-in improving implementation outcomes for the integrated TCM and Western medicine clinical practice guideline for stroke management.
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Am J Ophthalmol
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Centre for Public Health, Faculty of Medicine and Health Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom. Electronic address:
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View Article and Find Full Text PDFManure application increases soil doxycycline and zinc levels and resistance gene abundance.
Ecotoxicol Environ Saf
January 2025
College of Resources and Environmental Sciences, Southwest University, Chongqing 400715, China. Electronic address:
Doxycycline (DOX) and zinc (Zn), are frequently detected in livestock manure. Untreated excrement carries a sizable load of DOX and Zn into the soil, exacerbating agricultural nonpoint source pollution. However, research on the effects of DOX and Zn on soil microbial diversity and the prevalence of resistance genes is limited.
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