Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2466/pr0.1983.52.2.523 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Remimazolam vs Midazolam on Early Postoperative Cognitive Recovery in Elderly Patients Undergoing Dental Extraction: A Prospective Randomized Controlled Study.
Drug Des Devel Ther
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Purpose: Elderly patients undergoing dental extraction are particularly susceptible to delayed cognitive recovery after sedation. This study aimed to compare the effects of remimazolam and midazolam on early postoperative cognitive recovery in elderly patients undergoing dental extraction.
Patients And Methods: This was a single-centre randomized controlled study with elderly patients scheduled for receiving dental extraction under sedation of remimazolam (Group R) or midazolam (Group M).
Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder.
Clin Psychopharmacol Neurosci
November 2024
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Objective: Bipolar disorder (BD) is marked by significant change in mood and energy levels with sleep disturbance a common feature, resulting in diminished quality of life and impaired daily functioning. This study assessed the association between BD-polygenic risk scores (PRS) and hypnotics in bipolar I disorder (BD-I) patients.
Methods: Large-sample data were collected from the genome-wide association study of a multicenter Bipolar Genomic Study, and 1,394 BD-I patients with available medication information were divided into two groups depending on whether they used hypnotics or not.
Dexmedetomidine attenuates sepsis-associated acute lung injury by regulating macrophage efferocytosis through the ROS/ADAM10/AXL pathway.
Int Immunopharmacol
December 2024
Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China. Electronic address:
Background: The lungs are highly susceptible to damage during sepsis, with severe lung injury potentially progressing to acute respiratory distress syndrome and even fatal sepsis. Effective efferocytosis of apoptotic cells is crucial in alleviating inflammation and tissue injury.
Methods: We established a septic lung injury mouse model via intraperitoneal injection of lipopolysaccharide.
Dexmedetomidine alleviates CoCl2-induced hypoxic cellular damage in INS-1 cells by regulating autophagy.
Korean J Anesthesiol
December 2024
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Ischemia-reperfusion injury during surgery can damage pancreatic cells, and autophagy, which is a cell's self-repair mechanism, plays a significant role in this process, especially under hypoxic conditions.
- This study investigates how dexmedetomidine, a sedative, impacts pancreatic β-cell health by regulating autophagy when exposed to hypoxia induced by cobalt chloride.
- Results show that dexmedetomidine helps protect these cells by reducing harmful autophagy levels and preventing cell death, suggesting it could have potential therapeutic benefits worth exploring further in clinical settings.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!