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Oxidative stress drives potent bactericidal activity of pyrazinamide against .
bioRxiv
December 2024
Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
Pyrazinamide (PZA) is a critical component of tuberculosis first-line therapy due to its ability to kill both growing and non-replicating drug-tolerant populations of within the host. Recent evidence indicates that PZA acts through disruption of coenzyme A synthesis under conditions that promote cellular stress. In contrast to its bactericidal action , PZA shows weak bacteriostatic activity against in axenic culture.
View Article and Find Full Text PDFDioxygen reductase heterogeneity is crucial for robust aerobic growth physiology of .
iScience
December 2024
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra 400005, India.
The development of a system to leverage molecular oxygen for energy-efficient pathways required several molecular adaptations. The enzymatic reduction of dioxygen to water is one such prominent evolutionary molecular trait. Microbes evolved several enzymes capable of reducing dioxygen and, interestingly, retained multiples of them in their genomes.
View Article and Find Full Text PDFA novel and alternative treatment method for moderate diabetic foot ulcer: tibial periosteal distraction.
J Orthop Surg Res
December 2024
Diabetic Foot Treatment Centre, Peking University People's Hospital, Peking University, Beijing, China.
Objective: Researchers have proposed a novel surgical treatment for moderate diabetic foot ulcer: tibial periosteal distraction (TPD) which could improve affected limb microcirculation. We aimed to describe the method and therapeutic effects of this technique.
Methods: We provided a technical guide to perform TPD surgery for the treatment of moderate diabetic foot ulcer of who had been treated in our department.
Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer.
Redox Biol
February 2025
Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland.
The increase in early-stage cancers, particularly gastrointestinal, breast and kidney cancers, has been linked to lifestyle changes such as consumption of processed foods and physical inactivity, which contribute to obesity and diabetes - major cancer risk factors. Conventional treatments such as chemotherapy and radiation often lead to severe long-term side effects, including secondary cancers and tissue damage, highlighting the need for new, safer and more effective therapies, especially for young patients. Weak electromagnetic fields (WEMF) offer a promising non-invasive approach to cancer treatment.
View Article and Find Full Text PDFIsoquinolinequinone N-oxides with diverging mechanisms of action induce collateral sensitivity against multidrug resistant cancer cells.
Eur J Pharmacol
February 2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135, Porto, Portugal; Cancer Drug Resistance Group, IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, 4200-135, Porto, Portugal; FFUP - Faculty of Pharmacy of the University of Porto, 4050-313, Porto, Portugal. Electronic address:
Multidrug resistance (MDR) is a major challenge in cancer research. Collateral sensitizers, compounds that exploit the enhanced defense mechanisms of MDR cells as weaknesses, are a proposed strategy to overcome MDR. Our previous work reported the synthesis of two novel Isoquinolinequinone (IQQ) N-oxides that induce collateral sensitivity in MDR ABCB1-overexpressing non-small cell lung cancer (NSCLC) and colorectal cancer cells.
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