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Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression.
J Nanobiotechnology
January 2025
Department of Orthopedics, Zhuhai Medical College (Zhuhai People's Hospital), State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Chemistry and Materials Science, Jinan University, Zhuhai, 519000, China.
Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. Oxidative damage and inflammation are critical factors in secondary pathological processes. Selenium nanoparticles have demonstrated significant antioxidative and anti-inflammatory properties via a non-immunosuppressive pathway; however, their clinical application has been limited by their inadequate stability and functionality to cross the blood-spinal cord barrier (BSCB).
View Article and Find Full Text PDFSelenium nanoparticles modified niobium MXene for non-enzymatic detection of glucose.
Sci Rep
January 2025
Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
Article Synopsis
- Glucose sensing is essential for managing diabetes, and this study explores NbCT-selenium nanoparticles for effective nonenzymatic glucose detection.
- The composite material was characterized using techniques like scanning and transmission electron microscopy, and it was tested on a gold disc electrode in an alkaline solution.
- The sensor operates at a low overpotential of 0.16 V, demonstrating a detection range of 2 to 30 mM, with a notable sensitivity of 4.15 µA mM cm and a detection limit of 1.1 mM.
The mediating role of inflammatory biomarkers in the association between serum copper and sarcopenia.
Sci Rep
January 2025
The Orthopaedic Medical Center, Second Hospital of Jilin University, Changchun, Jilin Province, China.
This study aims to investigate the association between serum copper (Cu), selenium (Se), zinc (Zn), Se/Cu and Zn/Cu ratios and the risk of sarcopenia. In this study, which involved 2766 adults aged ≥ 20 years enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016, multivariable logistic regression, restricted cubic spline (RCS) models and mediation analyses were used. After full adjustment, multivariable logistic regression revealed that higher serum copper levels were correlated with an increased risk of sarcopenia.
View Article and Find Full Text PDFNutritional Dermatology: Optimizing Dietary Choices for Skin Health.
Nutrients
December 2024
Department of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA.
Background/objectives: Youthful, smooth skin is highly desired in modern society. Individuals invest in cosmetics, plastic surgeons, and dermatologists in pursuit of perfect skin. However, many do not seek out dietary changes to improve skin health.
View Article and Find Full Text PDFMicronutrient Deficiencies in Heart Failure and Relationship with Exocrine Pancreatic Insufficiency.
Nutrients
December 2024
Department of Cardiology, University Medical Centre Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Background: Micronutrient deficiencies are common and play a significant role in the prognosis of many chronic diseases, including heart failure (HF), but their prevalence in HF is not well known. As studies have traditionally focused on causes originating within the intestines, exocrine pancreatic insufficiency (EPI) has been overlooked as a potential contributor. The exocrine pancreas enables the absorption of various (fat-soluble) micronutrients and may be insufficient in HF.
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