AI Article Synopsis
Article Abstract
In 12 of 21 cystinuric patients, the components of cystine stones, either previously passed or removed at surgery, were studied by X-ray diffractometry and chemical analysis. The results of diffractometry suggested that, in addition to cystine, the stones contained sodium urate and ammonium magnesium orthophosphate hydrate, although chemical analysis was negative for these components. The role of uric acid in cystinuria is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000474088 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Urolithiasis is a multifactorial condition where stone composition is critical in guiding treatment and prevention strategies. Advanced diagnostic techniques, such as infrared spectroscopy, provide precise stone analysis, enabling clinicians to tailor interventions based on specific stone types and associated metabolic abnormalities. Calcium oxalate monohydrate stones often require invasive approaches like percutaneous nephrolithotomy, while uric acid responds well to dissolution therapy.
View Article and Find Full Text PDFA study of the difference in biochemical metabolism between patients with unilateral and bilateral upper urinary tract stones.
Sci Rep
December 2024
Department of Urology, Qinghai University Affiliated Hospital, Xining, 810000, China.
Article Synopsis
- Bilateral upper urinary tract stones are more likely to cause kidney function issues compared to unilateral stones, and a study analyzed data from 555 patients to explore metabolic differences between these groups.
- The study found that male patients and those with hyperuricemia had a higher risk of developing bilateral stones, with distinct metabolic abnormalities found, including low urine volume and higher levels of uric acid and creatinine.
- Results suggest that increasing water intake can help prevent stone formation, especially in patients with elevated uric acid levels.
The potential role of Sodium/Glucose Cotransporter 2 inhibitors in the treatment of cystinuria.
Urolithiasis
November 2024
Department of Urology, University of California San Francisco, San Francisco, CA, USA.
The Maillard reaction is a non-enzymatic reaction between an amino acid and carbohydrate. We hypothesized that continuous washing of cystine stones with glucose could theoretically prevent growth of an existing cystine stone or even reduce its size leading to a decrease in stone events. Sodium/Glucose Cotransporter 2 (SGLT2) inhibitors, well known for inducing glucosuria, were used to test this hypothesis in an initial series of patients.
View Article and Find Full Text PDFDiscovery of l-Lysine Dioxalate (LH1513) as a Novel Inhibitor of Calcium Oxalate Crystallization for Hyperoxaluria.
ACS Med Chem Lett
November 2024
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Article Synopsis
- - Hyperoxaluria leads to high levels of oxalate in urine, resulting in the formation of calcium oxalate (CaOx) kidney stones, and there's a need for better treatment options.
- - Researchers discovered a new compound, l-lysine dioxalate (LH1513), which is a stronger inhibitor of CaOx crystallization than existing substances like citrate and pyruvate.
- - A prodrug version of LH1513 shows good absorption when taken orally and has been tested in a preliminary study on mice, showing potential in preventing the formation of urinary CaOx crystals associated with hyperoxaluria.
Urinary Stone Composition Analysis of 1465 Patients: The First Series from Azerbaijan.
Arch Iran Med
November 2024
Department of Laboratory, State Security Service Military Hospital, Baku, Azerbaijan.
Article Synopsis
- - The study focuses on urinary stone disease in Azerbaijan, analyzing the composition of stones from 1,465 patients using FTIR spectroscopy over nearly a decade.
- - Findings indicate that calcium oxalate stones are the most common type at 56.2%, with uric acid stones following at 33.7%, and show variations based on age and gender.
- - The research suggests a need for customized diagnostic and treatment strategies due to the high prevalence of urinary stones, especially mixed types, highlighting the complexity of this health issue.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!