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Dosimetric investigation of couch rotation angles in non-coplanar VMAT plans for lung cancer SBRT.
Front Oncol
December 2024
Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: This study aimed to investigate the effect of couch rotation angles on non-coplanar volumetric modulated arc therapy (ncVMAT) plan for stereotactic body radiotherapy (SBRT) in lung cancer patients and to evaluate the feasibility of clinically applying ncVMAT for SBRT.
Methods: Twenty-four lung cancer patients with a single lesion eligible for SBRT were enrolled in the study. Seven dual partial-arc VMAT plans with varying couch angles were designed for every patient.
Radiosurgery-induced early changes in peritumoral tissue sodium concentration of brain metastases.
PLoS One
November 2024
Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Background: Stereotactic radiosurgery (SRS) is an effective therapy for brain metastases. Response is assessed with serial 1H magnetic resonance imaging (MRI). Early markers for response are desirable to allow for individualized treatment adaption.
View Article and Find Full Text PDFNebulized Dexmedetomidine Alleviates Oxidative Stress in Ventilator-induced Lung Injury via Keap1-Nrf2-ARE Pathway.
Iran J Allergy Asthma Immunol
May 2024
Department of Anesthesiology, The Second Affiliated Hospital, Soochow University, Suzhou, China.
This study aimed to explore the underlying mechanism of nebulized dexmedetomidine (DEX) in ameliorating ventilator-induced lung injury (VILI)-induced oxidative stress in rats. Forty 7 to 8-week-old Sprague-Dawley rats at the specific pathogen-free level were randomized into the control group, model group, nebulized dexmedetomidine (WH-YM) group, and dexmedetomidine intravenous infusion (JM-YM) group, each containing 10 rats. Except for the control group, rats in the other groups underwent mechanical ventilation (tidal volume, 40 mL/kg; respiratory rate, 70 breaths per minute; inspiratory-to-expiratory ratio, 1:2; fraction of inspired oxygen, 21%; positive end-expiratory pressure, 0 cmH2O).
View Article and Find Full Text PDFThe Effect of Photobiomodulation on Bone Mineral Density, Serum Vitamin D, and Bone Formation Markers in Individuals with Complete Spinal Cord Injuries with Osteoporosis.
Photobiomodul Photomed Laser Surg
November 2024
Poorsina Hospital, Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Article Synopsis
- - A quasi-experimental study tested the effects of photobiomodulation (a type of laser therapy) on bone mineral density (BMD) in eight patients with complete spinal cord injury and osteoporosis, applying the treatment on one side of the body and using the other side as a control.
- - The treatment involved using a specific type of laser at various energy densities based on the bone's depth from the skin and was administered three times weekly for eight weeks, with BMD and vitamin D levels measured at the start, after treatment, and weeks later.
- - Results showed significant BMD improvements in the proximal-femur and forearm regions, along with increased vitamin D levels, although no changes were noted in other areas or
Dihydrotanshinone I targets ESR1 to induce DNA double-strand breaks and proliferation inhibition in hepatocellular carcinoma.
Phytomedicine
July 2024
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310000, China; Key Laboratory of Blood-Stasis-Toxin Syndrome of Zhejiang Province, Hangzhou, Zhejiang 310053, China; Traditional Chinese Medicine 'Preventing Disease' Wisdom Health Project Research Center of Zhejiang, Hangzhou 310053, China. Electronic address:
Background: Due to its high incidence and elevated mortality, hepatocellular carcinoma (HCC) has emerged as a formidable global healthcare challenge. The intricate interplay between gender-specific disparities in both incidence and clinical outcomes has prompted a progressive recognition of the substantial influence exerted by estrogen and its corresponding receptors (ERs) upon HCC pathogenesis. Estrogen replacement therapy (ERT) emerged for the treatment of HCC by administering exogenous estrogen.
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