Orientation of normal and 12 abnormal immunoglobulins G (IgG) isolated from serum of patients with multiple myeloma in monomolecular layers at 0.15 M NaCl--air and 0.15 M NaCl--octane interfaces has been studied. Majority of abnormal proteins was found to be oriented vertically at phase border of both types unlike normal human IgG which had horizontal orientation. Abnormal IgG differed from the normal one also by lower resistance to surface denaturation at air--water interface. Thus the monomolecular layer method was demonstrated to be capable of distinguishing normal and abnormal IgG.
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