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Olanzapine Versus Quetiapine: Corrected QT Changes in Critically Ill Patients.
Ann Pharmacother
October 2024
Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
Article Synopsis
- This study compares the effects of olanzapine and quetiapine on QTc prolongation in critically ill patients, as prior research in this area is limited.
- The analysis included patients in the ICU who received at least two doses of either medication and assessed QTc changes within 48 hours.
- Results indicated no significant differences in QTc prolongation between the two drugs, suggesting that they may have similar safety profiles for this condition in an ICU setting.*
Torsades de Pointes electrical storm in children with KCNH2 mutations.
BMC Med Genomics
October 2024
Department of Cardiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Article Synopsis
- Congenital long QT syndrome (LQTS) is a genetic heart condition that can cause serious arrhythmias, particularly in children, and can often be mistaken for epilepsy.
- This study highlights two children misdiagnosed with epilepsy who suffered life-threatening cardiac events linked to specific mutations in the KCNH2 gene, found through whole exome sequencing.
- The findings emphasize the importance of evaluating cardiovascular health in patients with epilepsy, especially those with unusual symptoms, and suggest treatment options like Nadolol, cardiac sympathetic denervation, or an implantable cardioverter-defibrillator (ICD) for high-risk LQT2 patients.
An Updated Safety Review of the Relationship Between Atypical Antipsychotic Drugs, the QTc Interval and Torsades de Pointe As: Implications for Clinical Use.
Expert Opin Drug Saf
September 2024
Westchester Medical Center, New York Medical College, Departments of Cardiology and Medicine, Valhalla, NY, USA.
Introduction: The rising prevalence of psychiatric disorders has resulted in a significant increase in the use of antipsychotic medications. These agents may prolong the corrected QT interval (QTc), running the risk of precipitating ventricular arrhythmias, notably Torsades de Pointes (TdP). Current recommendations vary regarding the optimal approach to safe prescribing practices and QTc surveillance for antipsychotics.
View Article and Find Full Text PDFThe atypic antipsychotic clozapine inhibits multiple cardiac ion channels.
Naunyn Schmiedebergs Arch Pharmacol
January 2023
High Content Biology, Integrated Drug Discovery, Sanofi-Aventis R&D, 13 quai Jules Guesde, 94403, Vitry-sur-Seine, France.
Clozapine is an atypical neuroleptic used to manage treatment-resistant schizophrenia which is known to inhibit cardiac hERG/K11.1 potassium channels, a pharmacological property associated with increased risk of potentially fatal Torsades de Pointes (TdP) and sudden cardiac death (SCD). Yet, the long-standing clinical practice of clozapine does not show a consistent association with increased incidence of TdP, although SCD is considerably higher among schizophrenic patients than in the general population.
View Article and Find Full Text PDFLong QT syndrome with potassium voltage-gated channel subfamily H member 2 gene mutation mimicking refractory epilepsy: case report.
BMC Neurol
September 2021
Department of Neurology and Radiology & Biomedical Imaging, Epilepsy Center, University of California, San Francisco, California, 94143-0628, USA.
Background: Epileptic seizures can be difficult to distinguish from other etiologies that cause cerebral hypoxia, especially cardiac diseases. Long QT syndrome (LQTS), especially LQTS type 2 (LQT2), frequently masquerades as seizures because of the transient cerebral hypoxia caused by ventricular arrhythmia. The high rate of sudden death in LQTS highlights the importance of accurate and early diagnosis; correct diagnosis of LQTS also prevents inappropriate treatment with anti-epileptic drugs (AEDs).
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