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Identifying genetic susceptibility loci associated with human coronary artery disease.
PLoS One
January 2025
Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Coronary artery disease (CAD) is a multigenic condition influenced by both nature and nurture (60% to 40%). Prognosis of CAD is based on familial patterns. This study examined and analyzed the susceptibility of CAD to genetic variants in various Pakistani families.
View Article and Find Full Text PDFBackground: Plasma biomarkers of Alzheimer's disease (AD) are less invasive and have lower costs than cerebrospinal fluid (CSF) biomarkers. Blood biomarkers are potential instruments for diagnosis, prognosis, and monitoring of disease progression. We assessed the diagnostic potential of several plasma biomarkers for the detection of early stages of AD.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Department of pharmaceutical engineering & technology, Varanasi, UP, India.
Background: Alzheimer's disease (AD) is a brain related neurological disorder characterized by gradual loss in memory along with other peripheral and central symptoms. The currently available treatments for AD provide only symptomatic relief without addressing the pathological hallmarks of the disease, therefore, neurodegeneration continues with these therapies.
Method: The novel unique NIRF probes were designed, characterized with help of NMR techniques followed by biological evaluation against amyloid-β (Aβ) and cholinesterases (ChEs) through various in-vitro studies.
Developing Topics.
Alzheimers Dement
December 2024
University of Kentucky College of Medicine, Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: Our lab recently developed 2 mouse monoclonal antibodies that preferentially react with "distressed astrocytes". One monoclonal, 26A6, was found to react preferentially with a form of the Ca2+/calmodulin-dependent protein phosphatase, calcineurin (CN), that has been cleaved by calpain, to generate a 48 kDa CN fragment (∆CN). We recently published a characterization of this antibody.
View Article and Find Full Text PDFA Case of Small-Cell Lung Cancer With Novel Anaplastic Lymphoma Kinase Gene Rearrangement That Developed Intradural Extramedullary Spinal Metastases With Myelitis.
Cureus
December 2024
Department of Neurology, International University of Health and Welfare Narita Hospital, Narita, JPN.
( gene rearrangement-positive small-cell lung cancer (SCLC) is extremely rare. A 73-year-old man was diagnosed with SCLC. Standard treatments were not effective.
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