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Nonarteritic Anterior Ischemic Optic Neuropathy and Semaglutide: What is This All About?
J Assoc Physicians India
August 2024
Consultant Physician and Diabetes Specialist, Department of Diabetes & Endocrinology, Shilpa Medical Research Centre, Mumbai, Maharashtra, India.
Nonarteritic anterior ischemic optic neuropathy (NAION) was first documented by a French physician Jean-Pierre Saint-Yves in 1817 (19th century). The clinical description of NAION was not known until 1935 when C. Miller Fischer thoroughly described it.
View Article and Find Full Text PDFImplications of Incorporating Plasma Lipoprotein Binding into a Physiologically-Based Pharmacokinetic Model: A Simulation Study with Amiodarone.
Clin Pharmacol Ther
May 2024
Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Although various lipophilic drugs are bound to lipoproteins, lipoprotein binding in plasma is not usually considered in current physiologically-based pharmacokinetic (PBPK) models. Amiodarone is extensively bound to serum triglyceride-rich lipoproteins. Total plasma amiodarone concentration, which is the sum of both unbound and bound concentrations, increases with increasing serum triglyceride levels.
View Article and Find Full Text PDFWhen a Cure Becomes a Curse: The Complex Clinical Scenario Involving Amiodarone Therapy and BRASH (Bradycardia, Renal failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome.
Cureus
May 2023
Cardiology, Saint Peter's University Hospital/Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
BRASH [bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia] syndrome is a recently recognized clinical condition that is rare but can be potentially life-threatening. Its pathogenesis is characterized by a self-perpetuating cycle of bradycardia that is potentiated by the concomitant occurrence of medication use, hyperkalemia, and renal failure. AV nodal blocking agents are commonly implicated in BRASH syndrome.
View Article and Find Full Text PDFThe predictive value of electrocardiographic polarization parameters on appropriate ICD shock in primary prevention heart failure patients.
J Electrocardiol
March 2023
Dokuz Eylul University, Faculty of Medicine, Heart Rhythm Management Center, Izmir, Turkey.
Object: The effect of frontal QRS-T angle, Tp-e and Tp-e/QT ratio on cardiac events have been shown in many studies. In this study, we aimed to determine the prognostic value of frontal QRS-T angle, TPe and Tp-e/QT ratio on ICD shock in patients who had ICD (Implantable Cardioverter Defibrillator) implanted due to heart failure with reduced ejection fraction (HFrEF).
Material And Method: 158 patients with HFrEF who had previous ICD implantation were retrospectively analyzed.
Pharmacokinetics and pharmacodynamics of amiodarone in patients with hypertriglyceridemia: Two case reports.
Int J Clin Pharmacol Ther
December 2022
Background: The antiarrhythmic drug amiodarone has noncardiac adverse effects, leading to restrictive therapeutic plasma ranges. Despite the significant positive correlation between triglyceride and amiodarone levels, the effect of fluctuations in amiodarone levels in patients with hypertriglyceridemia on amiodarone therapy has not been fully characterized. This study is the first to report on the effect of hypertriglyceridemia on the efficacy and safety of amiodarone therapy.
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