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Therapeutic Potential of Carbon Dots Derived from Phytochemicals as Nanozymes Exhibiting Superoxide Dismutase Activity for Anemia.
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State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Anemia is a potentially life-threatening blood disorder caused by an insufficient erythroblast volume in the circulatory system. Self-renewal failure of erythroblast progenitors is one of the key pathological factors leading to erythroblast deficiency. However, there are currently no effective drugs that selectively target this process.
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Med Care
February 2025
RTI International, Research Triangle Park, NC.
Background: Telehealth services can increase access to care by reducing barriers. Telephone-administered care, in particular, requires few resources and may be preferred by communities in areas that are systemically underserved. Understanding the effectiveness of audio-based care is important to combat the current mental health crisis and inform discussions related to reimbursement privileges.
View Article and Find Full Text PDFMicro-Defects-Related Low Cycle Fatigue Mechanical Model of the Nuclear-Grade S30408 Stainless Steel.
Nanomaterials (Basel)
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Institute of Clean Energy, Yangtze River Delta Research Institute, Northwestern Polytechnical University, Taicang 215400, China.
Continuous and interrupted low cycle fatigue tests were conducted on nuclear-grade S30408 stainless steel under different stress conditions at room temperature. Vickers hardness testing and microstructure characterization were performed on the fatigue samples with different fatigue states. The evolutionary mechanism of the microstructure defects in materials under fatigue cyclic loading was discussed.
View Article and Find Full Text PDFBi-Hormonal Endocrine Cell Presence Within the Islets of Langerhans of the Human Pancreas Throughout Life.
Cells
January 2025
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada.
Bi-hormonal islet endocrine cells have been proposed to represent an intermediate state of cellular transdifferentiation, enabling an increase in beta-cell mass in response to severe metabolic stress. Beta-cell plasticity and regenerative capacity are thought to decrease with age. We investigated the ontogeny of bi-hormonal islet endocrine cell populations throughout the human lifespan.
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