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Empowerment in structures. Practical-ethical considerations of the preconditions for technology-assisted dementia care in Germany based on an expert-interview study.
Front Psychiatry
January 2025
Department of Medical Ethics and History of Medicine, University Medical Center Göttingen, Göttingen, Germany.
Background: Intelligent assistive technologies (IAT) have become more common in dementia care. Ethical reflection on technology-assisted dementia care (TADC) has focused so far mainly on individual and interpersonal implications (e.g.
View Article and Find Full Text PDFChallenges and improvement strategies in the hospitalization of chronic multimorbid patients.
World J Clin Cases
January 2025
Antequera Hospital, Northern Málaga Antequera Integrated Healthcare Area, Antequera 29200, Málaga, Spain.
Background: Addressing the growing challenge of hospitalizing chronic multimorbid patients, this study examines the strain these conditions impose on healthcare systems at a local level, focusing on a pilot program. Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes. If proven effective, this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.
View Article and Find Full Text PDFMetacaspases-Like Proteases of Trichomonas vaginalis: In Silico Identification and Characterization.
J Basic Microbiol
January 2025
Laboratorio de Bioquímica y Genética Molecular, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Metacaspases (MCA), are cysteine-dependent proteases closely related to caspases. In protozoa, MCA plays an important role in programmed cell death (PCD). In Trichomonas vaginalis, a kind of PCD that resembles apoptosis has been described, but the activators of this mechanism have not been demonstrated.
View Article and Find Full Text PDFAddressing Improper Medicine Storage Practices: Commentary on Louhisalmi et al.'s Study.
Basic Clin Pharmacol Toxicol
February 2025
Department of Addiction Psychiatry, Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan City, Taiwan.
Chronic stress profoundly affects the structure and function of the prefrontal cortex (PFC), a brain region critical for executive functions and emotional regulation. This review synthesizes current knowledge on stress-induced PFC plasticity, encompassing structural, functional, and molecular changes. We examine how chronic stress leads to dendritic atrophy, spine loss, and alterations in neuronal connectivity within the PFC, particularly affecting the medial PFC.
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