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A patient on long-term glucocorticoid therapy for peristomal pyoderma gangrenosum (PPG) who developed mucormycosis (MM) of the wound with dissemination was presented. The importance of skin biopsy, together with clinical evaluation in patients with PPG who are resistant to conventional therapy or who develop new symptoms related to their PPG is stressed. The risk and pathogenesis of invasive fungal infections with long-term corticosteroid therapy were explored.

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Article Synopsis
  • Laryngopharyngectomy defects can be reconstructed using various flaps, but the latissimus dorsi myocutaneous free flap (LDMFF) is highlighted as a strong option for high-risk patients with complex defects.
  • A study involving 24 patients showed a 100% flap survival rate, with some complications such as pharyngocutaneous and tracheo-esophageal fistulas, but most patients were able to sustain some oral intake.
  • The findings suggest that LDMFF is effective and has manageable complications, making it a viable choice for patients, especially those who have experienced radiation treatment.
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Cutaneous amebiasis is a rare clinical entity caused by the invasive protozoan parasite that can be readily diagnosed with skin biopsy if suspected. It presents as a rapidly progressive and destructive ulceration with necrosis. A man in his 40s with metastatic rectal cancer who underwent palliative abdominal perineal resection with end colostomy in his left lower quadrant and on systemic chemotherapy developed progressive breakdown of his peristomal skin unresponsive to antibiotics that was then diagnosed to be cutaneous amebiasis.

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