Transmembrane potentials were recorded in Purkinje fibers obtained from dogs aged 1 day, 1 week, 2 weeks, 4 weeks and more than 1 year. After the initial impalements there was a time-dependent increase in diastolic potential. This hyperpolarization was more pronounced in the younger Purkinje fibers. Maximum diastolic potentials from 1-day-old puppies (-78.0 +/- 1.2 mV), after 10 min of continuous impalement, were significantly less negative than those for adults (-84.2 +/- 1.9 mV). Fibers from neonates exposed to ouabain do not depolarize as much as fibers from adults.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000457289 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Papillary Muscles of the Left Ventricle: Integrating Electrical and Mechanical Dynamics.
J Cardiovasc Dev Dis
December 2024
Niculae Stancioiu Heart Institute, University of Medicine and Pharmacy "Iuliu Hatieganu", 400001 Cluj-Napoca, Romania.
Background: Papillary muscles are structures integrated into the mitral valve apparatus, having both electrical and mechanical roles. The importance of the papillary muscles (PM) is mainly related to cardiac arrhythmias and mitral regurgitation. The aim of this review is to offer an overview of the anatomy and physiology of the papillary muscles, along with their involvement in cardiovascular pathologies, including arrhythmia development in various conditions and their contribution to secondary mitral regurgitation.
View Article and Find Full Text PDFAssociation of Premature Ventricular Contraction (PVC) with hematological parameters: a data mining approach.
Sci Rep
January 2025
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Premature ventricular contraction (PVC) is characterized by early repolarization of the myocardium originating from Purkinje fibers. PVC may occur in individuals who are otherwise healthy. However, it may be associated with some pathological conditions.
View Article and Find Full Text PDFRole of CTRP14/C1QL1 in motor coordination and learning across the lifespan.
Physiol Behav
January 2025
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:
C1q/TNF-related protein 14 (CTRP14), also known as C1q-like 1 (C1QL1), is a synaptic protein predominantly expressed in the brain. It plays a critical role in the formation and maintenance of the climbing fiber-Purkinje cell synapses, ensuring that only one single winning climbing fiber from the inferior olivary neuron synapses with the proximal dendrites of Purkinje cells during the early postnatal period. Loss of CTRP14/C1QL1 results in incomplete elimination of supernumerary climbing fibers, leading to multiple persistent climbing fibers synapsing with the Purkinje cells.
View Article and Find Full Text PDFCardiac conduction system regeneration prevents arrhythmias after myocardial infarction.
Nat Cardiovasc Res
January 2025
Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.
Arrhythmias are a hallmark of myocardial infarction (MI) and increase patient mortality. How insult to the cardiac conduction system causes arrhythmias following MI is poorly understood. Here, we demonstrate conduction system restoration during neonatal mouse heart regeneration versus pathological remodeling at non-regenerative stages.
View Article and Find Full Text PDFConstruction of an animal model of autism based on interaction between cerebellar histological, immunohistochemical, and biochemical changes in adult male albino rat.
Ultrastruct Pathol
January 2025
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Methods: Twelve pregnant female rats were divided into a control group and a valproic acid (VPA) treated group (injected intraperitoneally on embryonic day 12 with 600 mg/kg body weight of VPA). Neurobehavioral tests were conducted on the offspring of both groups. The cerebellum was studied by light and electron microscopy as well as GFAP and caspase-3 immunohistochemical staining.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!