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Amiodarone Therapy: Updated Practical Insights.
J Clin Med
October 2024
Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Article Synopsis
- Amiodarone is a highly effective antiarrhythmic drug used to treat conditions like atrial fibrillation and ventricular arrhythmias, functioning across all four classes of antiarrhythmics.
- It has a long half-life and complex pharmacokinetics, which can lead to prolonged effects even after stopping the medication, making regular monitoring for side effects like thyroid issues and lung damage essential.
- This paper aims to offer a detailed review of amiodarone's uses, dosing guidelines, interactions with other medications, and necessary monitoring practices.
Results of the screening program for Fabry disease in patients with cornea verticillata at the University Hospital of Navarre.
Rev Clin Esp (Barc)
January 2023
Servicio de Medicina Interna, Hospital Universitari de Bellvitge, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Departamento de Ciencias Clínicas, Facultad de Medicina y Ciencias de la Salud, Universitat de Barcelona, Barcelona, Spain.
Introduction: Cornea verticillata (CV) or vortex keratopathy is characterized by the presence of spiral-shaped deposits in the corneal epithelium. The most frequent causes are antimalarial drugs and amiodarone and, among systemic causes, Fabry disease (FD).
Material And Methods: A multidisciplinary, prospective, descriptive study was conducted in a tertiary reference center in Spain's Autonomous Community of Navarre after the implementation of a FD screening program for patients attended to in the Ophthalmology Department.
Drug-induced corneal deposits: an up-to-date review.
BMJ Open Ophthalmol
April 2022
Ophthalmology, Centre Hospitalier de l'Université de Montreal, Montreal, Québec, Canada.
This review assesses different clinical aspects of the various known drug-induced corneal deposits, based on the corneal layer involved (epithelium, stroma and/or endothelium), and based on the drug class. The most well-known condition caused by drug deposits is vortex keratopathy, or corneal verticillata, which is a whorl-like opacity in the corneal epithelium. Vortex keratopathy is commonly caused by certain cationic amphiphilic drugs such as amiodarone, antimalarials, suramin, tamoxifen, chlorpromazine and non-steroidal anti-inflammatory drugs.
View Article and Find Full Text PDFIn vivo confocal microscopic images of atypical amiodarone-induced keratopathy in patient with epithelial basement membrane dystrophy.
Am J Ophthalmol Case Rep
June 2021
Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
A 73-year-old man presented with bilateral corneal opacities. Slit-lamp biomicroscopy showed vortex and oval-shaped opacities. confocal microscopy (IVCM) showed findings characteristic of amiodarone-induced keratopathy along with epithelial basement membrane dystrophy (EBMD).
View Article and Find Full Text PDFOcular Adverse Effects of Amiodarone: A Systematic Review of Case Reports.
Optom Vis Sci
July 2020
Department of Ophthalmology, Ochsner Health System, New Orleans, Louisiana.
Significance: Amiodarone is an excellent antiarrhythmic medication; however, it has numerous systemic and ocular adverse effects.
Purpose: We aimed to improve our understanding of amiodarone and its ocular adverse effects by performing a systematic review and meta-analysis of published case reports.
Methods: This systematic review was reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.
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