AI Article Synopsis
- A study of 24 cases linked enflurane anesthesia to liver damage, showing clinical signs similar to those from halothane and methoxyflurane.
- Postoperative fever was common, with jaundice appearing after an average of 8 days; prior exposure to enflurane or halothane shortened this onset period.
- Liver biopsies mainly showed centrilobular necrosis, and the injury is thought to be due to metabolic idiosyncrasy, indicating previous anesthesia exposure raises the risk of liver issues after enflurane use.
Article Abstract
Analysis of 24 cases of enflurane anesthesia-associated hepatic injury shows that the clinical, biochemical, and histologic features are similar to those seen with halothane- and methoxyflurane-related hepatitis. Postoperative fever was the presenting symptom in 19 patients. Jaundice occurred in 19 patients after a mean latent period of 8 days. Sixteen patients had been previously exposed to enflurane or halothane, and the latent period from exposure to the onset of symptoms or jaundice was shortened in these patients. There were five fatalities among the entire group. Liver biopsy most characteristically showed centrilobular necrosis, occasionally with ballooning degeneration and fatty change. The presumed mechanism of injury is metabolic idiosyncracy, and prior exposure to a haloalkane anesthetic may increase the risk of hepatic injury after enflurane administration.
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| http://dx.doi.org/10.7326/0003-4819-98-6-984 | DOI Listing |
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