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Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome?
Semin Reprod Med
March 2024
Department of Obstetrics and Gynecology, University of California, Los Angeles, California.
Anti-Müllerian hormone (AMH) is an important component within androgen receptor (AR)-regulated pathways governing the hyperandrogenic origin of polycystic ovary syndrome (PCOS). In women with PCOS, granulosa cell AMH overexpression in developing ovarian follicles contributes to elevated circulating AMH levels beginning at birth and continuing in adolescent daughters of PCOS women. A 6 to 7% incidence among PCOS women of gene variants coding for AMH or its receptor, AMHR2, suggests genetic contributions to AMH-related pathogenesis.
View Article and Find Full Text PDFTwo livebirths achieved in cases of hypergonadotropic hypogonadism nonobstructive azoospermia, treated with GnRH agonist and gonadotrophins: a case series and review of the literature.
JBRA Assist Reprod
August 2024
Fertility/FERTGROUP-Medicina Reprodutiva. São Paulo - SP, Brazil.
Non-obstructive azoospermia (NOA) is the most severe form of male factor infertility. It results form from either primary or secondary testicular failure. Here, we report cases of two patients with NOA due to maturation arrest and increased serum FSH, treated with GnRH agonist and gonadotrophins.
View Article and Find Full Text PDFUnraveling Hypothalamus-Pituitary dysregulation: Hypergonadotropism in F progeny due to prenatal exposure to hexavalent chromium.
J Biochem Mol Toxicol
April 2024
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, TAMU-4458, Texas A&M University, College Station, TX, USA.
The endocrine disruptor hexavalent chromium [Cr(VI)] is a proven reproductive toxicant. We recently demonstrated that prenatal Cr(VI) exposure causes testicular resistance to gonadotropins, resulting in hypergonadotropic hypoandrogenism in F rats. However, the mechanism driving hypergonadotropism in F rats exposed to Cr(VI) prenatally remains an enigma.
View Article and Find Full Text PDFOptimizing In Vitro Fertilization (IVF) Success in Hypergonadotropic Hypogonadism: A Case Study on the Impact of the Shanghai Protocol.
Cureus
February 2024
Clinical Embryology, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
This article evaluated the effect of the Shanghai protocol on a hypergonadotropic hypogonadism patient undergoing in vitro fertilization (IVF) treatment. Hypergonadotropic hypogonadism was characterized by low sex hormone levels and elevated gonadotropins, leading to infertility. Poor ovarian response and failed pregnancy outcomes were the results of previous IVF treatments using conventional stimulation methods.
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