Different types of epithelium in the human cervix are regularly found within circumscribed areas and obviously respect predetermined borderlines. The determination theory may explain these findings and could in consequence lead to the hypotheses of stromal regulation of the epithelium. Corresponding morphological changes of epithelium and associated stroma are evaluated as another relevant aspect. More or less obvious borderlines between two morphologically different environments are found in the stroma underlying epithelium with distinct borders. Such stroma changes were seen to be correlated to benign and neoplastic alterations of both squamous and cylindrical epithelium.
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