Physiological parameters of dogs conditioned reactions were studied, elaborated in response to experimental situations stimuli: in one case the animals experienced painful electrocutaneous stimulation (defensive situation), in the other one--they did not (neutral situation). One of these reflexes, that appearing in the defensive situation, may be considered as positive, the other one (in neutral situation)--as inhibitory. In conditions of transswitching, positive tonic conditioned reflex (TCR) determines positive signal significance of phasic (trigger) stimulus and inhibitory TCR--the negative significance (of the same stimulus). By conditions of elaboration, the inhibitory TCR resembles two types of internal inhibition--differential and delayed inhibition. At the same time the inhibitory TCR differs in such an important property as long duration. It determines its special functional inhibition. It is assumed that in integral behaviour TCR (positive and inhibitory) is a conditioned mechanism of regulation of levels of wakefulness and emotional states.
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Psychophysiology
January 2025
Department of Psychology, University of Bonn, Bonn, Germany.
Imaginal exposure is a standard procedure of cognitive behavioral therapy for the treatment of anxiety and panic disorders. It is often used when in vivo exposure is not possible, too stressful for patients, or would be too expensive. The Bio-Informational Theory implies that imaginal exposure is effective because of the perceptual proximity of mental imagery to real events, whereas empirical findings suggest that propositional thought of fear stimuli (i.
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Sorbonne University, CNRS, INSERM, Institute of Biology Paris Seine, Neurosciences Paris Seine, Paris, France.
Transitive inference, the ability to establish hierarchical relationships between stimuli, is typically tested by training with premise pairs (e.g., A + B-, B + C-, C + D-, D + E-), which establishes a stimulus hierarchy (A > B > C > D > E).
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January 2025
Dipartimento di Scienze Cognitive, Psicologiche, Pedagogiche e Degli Studi Culturali, Università di Messina, Messina, Italy.
Religious beliefs can shape how people process fear. Yet the psychophysiological mechanisms underlying this phenomenon remain poorly understood. We investigated fear learning and extinction processes in a group of individuals who professed a belief in God, compared to non-believers.
View Article and Find Full Text PDFLearn Mem
January 2025
Department of Psychology, Arizona State University, Tempe, Arizona 85287, USA
Chronic stress typically leads to deficits in fear extinction. However, when a delay occurs from the end of chronic stress and the start of fear conditioning (a "recovery"), rats show improved context-cue discrimination, compared to recently stressed rats or nonstressed rats. The infralimbic cortex (IL) is important for fear extinction and undergoes neuronal remodeling after chronic stress ends, which could drive improved context-cue discrimination.
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January 2025
Innovative Clinical Training, Trials & Healthcare Initiative, Zermatt CH-3920, Switzerland.
In order to disentangle the effects of drugs from placebo responses, several approaches have been used, such as a placebo run-in phase in which only placebo nonresponders, or poor responders, are considered for further randomization to either placebo or active treatment. This study is aimed at investigating the variability of placebo nonresponders obtained through the classical placebo run-in paradigm (group RUN) and through mismatch conditioning (group MIS), as done in our previous study. To do this, we simulated a real clinical trial in the laboratory, in which the placebo responders of both groups were discarded and the remaining nonresponders of both groups RUN and MIS were randomized to either continuing on placebo (groups RUN-P and MIS-P, respectively) or receiving topical 0.
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