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Obtained for many years experience of perioperative using of analgesics with peripheral effect is summarized. The special scientific analysis was carried out in 274 patients who got different analgesics with peripheral action (aspisol, baralgin, ketoprofen, ketorolak, contrikal) at different stages of preoperative period in combination with opioid. The control group included 30 patients who got monoanalgesia by promedol after abdominal operations.

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A fixed drug eruption to Baralgin (dipyrone) tablets.

West Indian Med J

December 1994

Department of Para-clinical Sciences, U.W.I., Trinidad.

Dipyrone-induced adverse skin reactions appear within the first seven days of drug administration, and the aetiology is often missed. A patient who regularly consumed dipyrone for dysmenorrhoea is presented. The adverse cutaneous manifestations may be predictive of the occurrence of severe haematological adverse reactions.

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There were performed clinical and biochemical investigations of nonnarcotic analgetic tramal application (FRG, Grunenthal) with 196 patients of orthopedic-traumatologic type. The conclusion was drawn that the most effective is tramal application in patients with chronic pains in case of purulent complications and the optimum combination is the coupling of tramal with baralgin and relanium.

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A comparative, randomized, double-blind study of diclofenac sodium 75 mg im versus Baralgin (a combination drug composed of dipyrone and two spasmolytics) 5 mL iv was performed on 57 patients with renal colic. Both groups were comparable as to age, sex, pain evolution time before treatment, and no treatment for renal colic in the six hours preceding trial drug administration. No significant differences were found between the two groups with respect to the evolution of pain after the first dose or in the frequency of administration of a second dose.

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Clophelinum (0.0014 +/- 0.00007 mg/kg, intravenously) as a component of multicomponent general anesthesia eliminated hemodynamic and endocrine reactions during major abdominal and thoracic surgery in cancer patients, reducing the dosage of calypsol and fentanyl.

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