In 20 volunteers, we were able to demonstrate experimentally that side-effects of anthralin application on healthy skin development of erythema and pigmentation, can be significantly reduced in a short contact therapy, in comparison to a longterm treatment. The oxydation products 1.8-dihydroxy-9.10-anthraquinone and 10.10'-dimer which are considered the main impurities of anthralin do not cause any irritation on healthy skin.
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