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Cytokine dynamics and quality of life: unraveling the impact of cell-free and concentrated ascites reinfusion therapy in ovarian cancer patients.
Int J Clin Oncol
January 2025
Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba, Iwate, 028-3695, Japan.
Background: The quality of life (QOL) of ovarian cancer patients is often impaired by refractory ascites. Cell-free and concentrated ascites reinfusion therapy (CART) is a palliative treatment for refractory ascites, but adverse events, such as fever, are problematic. Several cytokines have been suggested to be responsible for the adverse events, but they have not been investigated in detail.
View Article and Find Full Text PDFNovel Membrane Designed Polyether Sulfone Filter Reduces Filtration Membrane Obstruction Rate in Drop-Type With Adjustable Concentrator Cell-Free and Concentrated Ascites Reinfusion Therapy (DC-CART).
Artif Organs
December 2024
Department of Nephrology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Background: In cell-free and concentrated ascites reinfusion therapy (CART), filtration membrane obstruction during the ascites processing step is an important clinical problem. A novel membrane designed polyether sulfone filter (n-PES) was developed to reduce filter membrane obstruction. However, no clinical studies have compared the performance of n-PES filters with that of conventional filters.
View Article and Find Full Text PDFConcentrations of Irinotecan and SN-38 in the Ascites and the Fluid Product of Cell-Free and Concentrated Ascites Reinfusion Therapy 9 Days After Administration of Irinotecan in a Patient with Gastric Cancer: A Case Report.
Onco Targets Ther
November 2024
Department of Oncology and General Medicine, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Introduction: Cell-free and concentrated ascites reinfusion therapy (CART) is frequently used to relieve the symptoms caused by massive ascites due to peritoneal metastasis of gastric cancer, especially in the later stages of its clinical course. Irinotecan (CPT-11) is recommended for third- or later-line chemotherapy according to gastric cancer treatment guidelines. However, the concentrations of anti-cancer drugs in the ascites and the product of CART are not well known, it is considered that some amounts of anti-cancer drugs contained in the product of CART may be readministered and induce severe adverse reactions.
View Article and Find Full Text PDFRefractory bilateral chylothorax and chylous ascites in a patient with systemic lupus erythematosus treated by pleuro-peritoneal and peritoneal-venous shunts along with cell-free and concentrated ascites re-infusion therapy.
Respir Investig
November 2024
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga Prefecture, 849-8501, Japan.
Article Synopsis
- - A pleural effusion is a common issue for patients with systemic lupus erythematosus (SLE) and requires careful diagnosis for proper treatment.
- - The case discusses a rare occurrence of chylothorax in an SLE patient, which can be tough to manage despite strong immunosuppressive treatments, often leading to poor health and malnutrition due to frequent procedures.
- - To improve breathing and prevent malnutrition, treatments like pleuro-peritoneal and peritoneal-venous shunts, along with specialized therapies, may be useful.
Drainage of ascites in cirrhosis.
World J Hepatol
September 2024
Department of Gastroenterology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518000, Guangdong Province, China.
Article Synopsis
- - For managing refractory ascites in cirrhosis, diuretics, albumin, and vasoactive drugs are commonly used first, but their effectiveness is often limited.
- - When medication fails, various drainage techniques, such as large-volume paracentesis and shunts, are considered to manage fluid buildup.
- - The review discusses the pros and cons of these drainage methods, including their specific use cases and when they might not be appropriate.
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