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regionalpcs improve discovery of DNA methylation associations with complex traits.
Nat Commun
January 2025
Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
We have developed the regionalpcs method, an approach for summarizing gene-level methylation. regionalpcs addresses the challenge of deciphering complex epigenetic mechanisms in diseases like Alzheimer's disease. In contrast to averaging, regionalpcs uses principal components analysis to capture complex methylation patterns across gene regions.
View Article and Find Full Text PDFHow Latine youth's positive development unfold through farmwork in rural migrant farmworker families in the U.S. Midwest.
J Res Adolesc
March 2025
Department of Public Health, Purdue University, West Lafayette, Indiana, USA.
Some Latine youth from rural migrant farmworker communities engage in farmwork to help support themselves and their families. Although research has documented their motives for working and some characteristics of their employment, knowledge about how these youth construct their work in the fields and how such experiences relate to their positive development is needed to depict their holistic experiences. Using mixed methods, we explored youth's farmwork experiences and examined how these experiences relate to youth's prosocial behaviors, civic responsibility, and ego-resiliency.
View Article and Find Full Text PDFThe impact of artifact levels on intra- and interobserver agreement in pediatric urodynamic traces.
J Pediatr Urol
December 2024
Department of Pediatric Urology, Göztepe Prof. Dr Süleyman Yalcin City Hospital, Istanbul, Turkey.
Introduction: In pediatric urology, urodynamic studies are considered the most reliable method for assessing the function of the lower urinary tract. These evaluations play a particularly important role in guiding treatment decisions for neurogenic bladder conditions.
Objective: The aim of this study is to assess the impact of artifacts on the interobserver and intraobserver agreement in the interpretation of pediatric urodynamic traces.
Phylogenetics, biogeography, and life history evolution in the broadly distributed treefrog genus Dendropsophus.
Mol Phylogenet Evol
December 2024
Florida State University, Department of Biological Science, Center for Anchored Phylogenomics, Tallahssee, FL, USA.
Dendropsophusis one of the most species-rich genera of treefrogs. Recent studies integrating Sanger-generated mitochondrial and nuclear loci with phenomic characters (SP) have advanced understanding of this clade, but questions about its internal relationships and biogeographic history persist. To address these questions, we used anchored hybrid enrichment (AHE) to combine 432 nuclear loci for 78 taxa (72 % of species) with published data.
View Article and Find Full Text PDFCharacter strengths as predictors of general and academic self-efficacy in university students.
Front Psychol
December 2024
Escuela de Psicología, Facultad de Educación y Ciencias Sociales, Universidad Andrés Bello, Concepción, Chile.
Positive psychology has introduced the concept of character strengths, which are positive traits fundamental to well-being and mental health. Research on university students has shown that these strengths impact psychoeducational variables and personal functioning, acting as a protective factor in the general and student populations. This study aims to analyze the predictive relationships between character strengths and general self-efficacy and determine their joint contribution in predicting academic self-efficacy.
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