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Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent. | LitMetric

AI Article Synopsis

  • Technetium-99m-labeled sucralfate has been found to be stable and sensitive for visualizing gastric ulcers in both animal and human studies.
  • In tests, eight gastric ulcers were successfully visualized in rabbits, while in seven human studies, four showed true-positive results and three true-negative results.
  • The authors developed a method to label sucralfate with Tc-99m, suggesting it could have significant clinical benefits for diagnosing gastrointestinal ulcers and related conditions.

Article Abstract

Technetium-99m-labeled sucralfate, an ulcer-avid material, was shown in preliminary animal and human studies to be stable in vivo with good sensitivity. Eight experimentally produced discrete gastric ulcers in three rabbits were visualized using this material. Of seven human studies, four studies were true-positive and three were true-negative. It is suggested that Tc-99m-labeled sucralfate may prove to have significant clinical advantages for the evaluation of gastrointestinal ulcer disease and other diseases that are associated with loss of mucosal integrity. The method for labeling sucralfate with Tc-99m was developed by the authors.

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Source
http://dx.doi.org/10.1148/radiology.148.1.6856841DOI Listing

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