In a free-choice situation, chlordiazepoxide (CDP; 12.5 or 25 mg/100 ml; groups B or C), when incorporated in ethanol solutions (2 to 20%, v/v), caused a significant decrease in ethanol preference index (P.I.). This was probably due to the combined CNS effects of both drugs rather than a taste effect, since the mice did not discriminate between aqueous CDP solutions and water. However, when the mice had prior exposure to ethanol and CDP was incorporated intermittently, no significant decreases in P.I. resulted. In a no-choice situation, ethanol intake was increased only on the first day of each intermittent incorporation of CDP (3 days for each 6-day cycle), being more persistent in group B (2 to 15% ethanol) than in group C (2 to 6.5%). Ethanol intake decreased in group C when alcohol concentrations exceeded 10%. The "first-day" CDP effect also occurred in the no-choice situation of an ethanolic liquid diet. Possible factors for this effect are discussed. Thus the effects of CDP on alcohol consumption in non-deprived mice vary with experimental designs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0091-3057(83)90025-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Racial Disparities in Cardiometabolic Disorders Among Alzheimer's Disease Patients: A Study on Native Hawaiians and Pacific Islanders.
Cureus
December 2024
Department of Neurology, Hawaii Pacific Neuroscience, Honolulu, USA.
Background: Cardiometabolic disorders may accelerate the progression of Alzheimer's disease (AD), potentially impacting ethnic-racial groups with a higher prevalence of diabetes, obesity, and cardiovascular disease, though limited data exists on Native Hawaiians and Pacific Islanders (NHPI) populations.
Objective: This study aims to examine the prevalence of diabetes and associated comorbidities among AD patients from different ethnic-racial groups - Asians, Whites, and NHPIs - in Hawaii, with a focus on identifying risk factors linked to AD.
Method: A retrospective review was conducted on AD patient records from a single center in Hawaii, spanning June 2018 to June 2024.
Typhoid Fever as a Cause of Liver Failure in the United States: A Case Report.
Case Rep Gastrointest Med
January 2025
Department of Infectious Diseases, Maimonides Medical Center, Brooklyn, New York 11219, USA.
Typhoid fever is a multisystemic illness caused by and , transmitted fecal orally through contaminated water and food. It is a rare diagnosis in the US, with most cases reported in returning travelers. Hepatitis and cholestasis are rare sequelae of infection.
View Article and Find Full Text PDFPrediction and stratification for the surgical adverse events after minimally invasive esophagectomy: A two-center retrospective study.
World J Gastroenterol
January 2025
Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
Background: Minimally invasive esophagectomy (MIE) is a widely accepted treatment for esophageal cancer, yet it is associated with a significant risk of surgical adverse events (SAEs), which can compromise patient recovery and long-term survival. Accurate preoperative identification of high-risk patients is critical for improving outcomes.
Aim: To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with MIE.
Prevalence and associated factors of probable depression amongst pregnant and parenting young females: a comparison of adolescents and young adults in rural South Africa.
Front Child Adolesc Psychiatry
October 2023
DIMAMO Population Health Research Centre, University of Limpopo, Polokwane, South Africa.
Background: Pregnant teenagers have been reported to have an increased likelihood of experiencing depression than their non-pregnant peers. There is little research on the risk factors for depression in rural Black adolescents and young adults, especially after the Covid-19 pandemic. Therefore, the current study aimed to identify the prevalence of probable depression and associated factors amongst pregnant and parenting young females.
View Article and Find Full Text PDFAlcohol consumption and allergic diseases: Mendelian randomization evidence from China.
Glob Health Action
December 2024
College of Economics and Management, China Agricultural University, Beijing, China.
Background: The prevalence of allergic diseases in China has risen significantly over the past decades, affecting the quality of life for approximately 40% of the population.
Objectives: This study aimed to integrate survey and genomic data to explore the potential causal relationship between alcohol consumption and allergic diseases.
Method: In collaboration with a leading genetic testing company in China, we collected data on 3,041 participants via an online survey between December 2018 and October 2019.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!