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Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle.
Nat Nanotechnol
October 2024
Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Article Synopsis
- Exosomes have potential as treatments for tissue repair and boosting immune responses, especially in conditions like muscular dystrophy, but targeting them effectively in the body is challenging.
- This study introduces a new delivery system that uses ferromagnetic nanotubes to control where exosomes go in the body, specifically targeting skeletal muscles through an external magnetic field.
- Results showed that macrophages effectively take up these exosomes, enhancing muscle repair in a mouse model of Duchenne muscular dystrophy, paving the way for improved exosome-based therapies.
Oligodendrocyte precursor cells stop sensory axons regenerating into the spinal cord.
Cell Rep
September 2023
Department of Neural Sciences, Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:
Primary somatosensory axons stop regenerating as they re-enter the spinal cord, resulting in incurable sensory loss. What arrests them has remained unclear. We previously showed that axons stop by forming synaptic contacts with unknown non-neuronal cells.
View Article and Find Full Text PDFSkeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy.
J Cachexia Sarcopenia Muscle
October 2023
Department of Endocrinology and Metabolism, School of Life Sciences, Huashan Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Background: DJ-1 is a causative gene for Parkinson's disease. DJ-1-deficient mice develop gait-associated progressive behavioural abnormalities and hypoactive forearm grip strength. However, underlying activity mechanisms are not fully explored.
View Article and Find Full Text PDFIncreasing muscle contractility through low-frequency stimulation alters tibial bone geometry and reduces bone strength in and dystrophic mice.
J Appl Physiol (1985)
July 2023
Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by mutations or deletions in the dystrophin gene, for which there remains no cure. As DMD patients also develop bone fragility because of muscle weakness and immobilization, better understanding of the pathophysiological mechanisms of dystrophin deficiency will help develop therapies to improve musculoskeletal health. Since alterations in muscle phenotype can influence bone structure, we investigated whether modifying muscle contractile activity through low-frequency stimulation (LFS) could alter bone architecture in mouse models of DMD.
View Article and Find Full Text PDFTrichoscopic Findings in Pressure Alopecia: Report of Two Cases and Review of the Literature.
Int J Trichology
November 2021
Department of Dermatology, University Hospital San Cecilio, Granada, Spain.
Pressure alopecia (PA) is an uncommon type of hair loss due to ischemic changes of the scalp, as a result of prolonged immobilization. Clinically, it often appears within the 1 month of the trigger and tends to resolve spontaneously within 4 months. If the duration of the immobilization is longer, irreversible alopecia can be developed.
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