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Pharmacokinetics of aspirin: evaluating shortcomings in the literature.
Expert Opin Drug Metab Toxicol
August 2024
Focus Area for Human Metabolomics, North-West University, Potchefstroom, South Africa.
Article Synopsis
- - Aspirin is effective for preventing strokes and relieving pain, but its toxicity in some individuals is not well understood, particularly regarding the role of glycine conjugation in its detoxification process.
- - A review of existing literature highlighted the pharmacokinetics of aspirin and the factors influencing its metabolism, noting a lack of clarity around individual enzyme contributions and interindividual variation.
- - The review points out the need for more research on the substrate preferences of the enzyme responsible for aspirin activation and emphasizes that impaired glycine conjugation may contribute to serious health issues like Reye's syndrome and cancer.
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