Chest radiographs (n = 2000) of the public health office of Eutin were evaluated for the frequency of goitre in northern West-Germany. Up to the 40th year of age the frequency was 5%. Thereafter the prevalence of goitre-suspect radiographs gradually rose to 25% and to 50% after the 65th year of life. The radiographic method indicates that endemic goitre exists in Schleswig-Holstein as was to be expected due to formerly demonstrated alimentary iodine deficiency.
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http://dx.doi.org/10.1055/s-2008-1069686 | DOI Listing |
J Immunoassay Immunochem
January 2025
Internal Medicine and Endocrinology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Background: Numerous genes are involved in immune system modulation, and their polymorphisms may contribute to developing autoimmune disorders. Genetic variation contributes significantly to disease susceptibility to autoimmune thyroid disease (AITD).
Objectives: This work aims to investigate the role of single-nucleotide polymorphisms (SNPs) of interferon induced with helicase C domain 1 (IFIH1) rs1990760 and glutamate decarboxylase (GAD) rs769404 in AITD development.
Sci Rep
November 2024
Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, South Korea.
The purpose of this study was to evaluate the clinical feasibility and reliability of a neural network (NN)-based automated proptosis measurement system using computed tomography (CT) images. An automated proptosis measurement system was developed using the CT images of 200 eyes from 100 patients diagnosed with thyroid-associated orbitopathy. We compared the proptosis value obtained from the proposed automated system with the values obtained from the Hertel exophthalmometer and manual measurements of CT slices.
View Article and Find Full Text PDFEye (Lond)
January 2025
The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel, Affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background: Sympathetic overstimulation of Müller's muscle is a suggested mechanism underlying upper eyelid retraction in thyroid eye disease (TED). We examined the effect of tamsulosin, an alpha-1 antagonist, on eyelid retraction in patients with TED.
Methods: A single-centre prospective study.
Otol Neurotol
September 2024
Department of Head & Neck Surgery, Kaiser Permanente Oakland Medical Center.
Objectives: To evaluate otologic adverse reactions (OARs), including hearing loss (OARs-HL) among patients taking teprotumumab, a new biologic approved for the treatment of active thyroid eye disease, using publicly available pharmacovigilance reporting data.
Study Design: Retrospective database review.
Methods: The Food and Drug Administration Adverse Events Reporting System (FAERS) was queried for cases involving teprotumumab from 2020Q1 to 2023Q1.
Endocrine
November 2024
Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Purpose: Aimed to create a nomogram using clinical and eye-specific metrics to predict the efficacy of intravenous glucocorticoid (IVGC) therapy in patients with active and moderate-to-severe Thyroid-Associated Ophthalmopathy (TAO).
Methods: This study was conducted on 84 eyes from 42 moderate-to-severe TAO patients who received systemic IVGC therapy, and 42 eyes from 21 controls. Data were collected retrospectively from June 2020 to December 2021.
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