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[Exploration of CCL11 and sTNFR2 as potential biomarkers for the efficacy of lymphocyte immunotherapy in women with unexplained recurrent spontaneous abortion].
Zhonghua Fu Chan Ke Za Zhi
January 2025
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, State Key Laboratory of Female Fertility Promotion, National Clinical Research Center for Obstetric and Gynecologic Diseases, Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing100191, China.
To explore biomarkers for the efficacy of lymphocyte immunotherapy (LIT) treating women with unexplained recurrent spontaneous abortion (URSA). Serum samples from 24 URSA potients who received LIT were collected at Peking University Third Hospital from December 2014 to June 2015. Semiquantitative sandwich-based antibody arrays containing 40 cytokines were used to screen target immune cytokines in the peripheral blood of URSA patients before and after LIT.
View Article and Find Full Text PDFCLINICAL AND LABORATORY PREDICTORS OF ADVERSE OUTCOME WITH SEVERE COVID-19 IN COMORBID PATIENTS OF THE KARAGANDA REGION, REPUBLIC OF KAZAKHSTAN.
Georgian Med News
November 2024
4Health Administration of the Karaganda Region, Karaganda, Republic of Kazakhstan.
Aim Of The Study: Analysis of clinical, laboratory and instrumental parameters in comorbid patients with severe COVID-19.
Methods: A retrospective analysis was conducted on clinical, laboratory and instrumental parameters in patients with laboratory-confirmed severe COVID-19 taking into account the treatment outcome (recovery or lethal outcome). A multifactor logistic regression model was utilized to identify factors influencing lethal outcome in patients with severe COVID-19.
Predictive factors for clinical cure in the treatment of HBeAg(-) chronic hepatitis B or compensated cirrhosis: a prospective observational study.
Front Med (Lausanne)
January 2025
Department of Hepatobiliary and Pancreatic Medicine, The First Hospital of Jilin University Changchun, Changchun, Jilin, China.
Background: Sequential or combined treatment with nucleos(t)ide analogs (NAs) and pegylated interferon alpha-2b (Peg-IFN--2b) can improve the clinical cure rate. However, its clinical application is limited due to the adverse reactions associated with IFN.
Methods: A multi-center prospective observational study was conducted involving 59 NAs-treated chronic hepatitis B (CHB) patients who were treated with a combination therapy of NAs and Peg-IFN--2b for 48 weeks.
High output stoma after surgery for rectal cancer - a risk factor for low anterior resection syndrome?
BMC Gastroenterol
January 2025
Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, China.
Purpose: The relationship between high-output stoma (HOS) and low anterior resection syndrome (LARS) was previously unclear. This study investigated the association between HOS and major LARS in rectal cancer patients with preventive stoma.
Methods: We conducted a retrospective analysis of 653 rectal cancer patients who underwent prophylactic ileostomy reversal after low anterior resection at the Fourth Hospital of Hebei Medical University between 2018 and 2021.
Tumor aggression-defense index-a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer.
J Transl Med
January 2025
Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjiang, 150001, People's Republic of China.
Background: Although the TNM staging system plays a critical role in guiding adjuvant chemotherapy for colorectal cancer (CRC), its precision for risk stratification in stage II and III CRC patients with proficient DNA mismatch repair (pMMR) remains limited. Therefore, precise predictive models and research on postoperative treatments are crucial for enhancing patient survival and improving quality of life.
Methods: This retrospective study analyzed 1051 pMMR CRC patients who underwent radical resection and were randomly assigned to training (n = 736) and validation (n = 315) groups.
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