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Addition by Subtraction: Reversing Epikeratophakia and Stromal Scarring in a Patient With Myopia Magna.
Cornea
January 2025
Institut für Refraktive und Ophthalmo-Chirurgie (IROC), Zurich, Switzerland.
Purpose: To describe a three-phase surgical approach for managing progressive visual decline in a patient with myopia magna and a history of epikeratophakia.
Methods: A 55-year-old woman with previous epikeratophakia surgery in both eyes experienced progressive visual deterioration. The three-phase approach included: (1) removal of the epikeratophakia lenticule, (2) cataract extraction with intraocular lens implantation, and (3) transepithelial topography-guided photorefractive keratectomy (trans-PRK).
Effects of topical neutral protamine Hagedorn insulin on corneal wound healing: an experimental study in rabbits.
Biotech Histochem
January 2025
Faculty of Veterinary Medicine, Department of Pathology, Siirt University, Siirt, Turkiye.
Corneal injuries are common in human and veterinary ophthalmology. There are many studies which have investigated the treatment of corneal epithelial defects. This study aimed to investigate the effects of Neutral Protamine Hagedorn (NPH) insulin as an ointment for wound healing in experimental corneal defects.
View Article and Find Full Text PDFSMILE-Derived Corneal Stromal Lenticule: Experimental Study as a Corneal Repair Material and Drug Carrier.
Cornea
January 2025
Chongqing Eye and Vision Care Hospital Aier Eye Hospital Group, Yu Zhong, Chongqing, China.
Purpose: A detailed study of the physicochemical properties of SMILE-derived lenticules and evaluation of their drug delivery after loading with silver nanoparticles (AgNPs).
Methods: The lenticules were decellularized and modified with crosslinking concentrations of 0.01 (0.
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes.
BMC Genomics
January 2025
Department of Ophthalmology & Vision Science, School of Medicine, University of California Davis, Sacramento, CA, USA.
Purpose: Corneal dysmorphologies (CDs) are typically classified as either regressive degenerative corneal dystrophies (CDtrs) or defective growth and differentiation-driven corneal dysplasias (CDyps). Both eye disorders have multifactorial etiologies. While previous work has elucidated many aspects of CDs, such as presenting symptoms, epidemiology, and pathophysiology, the genetic mechanisms remain incompletely understood.
View Article and Find Full Text PDFMitochondrial Localization of Antioxidant Nanodrug Suppresses Ocular Inflammation by Alleviating Oxidative Stress on Cells.
Chemistry
January 2025
Wenzhou Medical University, 270 Xueyuan Road, 325027, Wenzhou, CHINA.
External environments (e.g., pollutants, irritants, ultraviolet radiation, etc) probably activate oxidative stress on the ocular surface, further leading to inflammatory responses and cellular apoptosis.
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