In early or mild carpal tunnel syndrome (CTS), where the segment of median nerve sensory fibers is neurapraxic, stimulation of the nerve distal to the carpal ligament elicits a normal response in comparison to the segment of nerve across the carpal tunnel. In 100 hands of 50 normal adults, palmar stimulation of the median sensory fibers at 7 cm was compared to that at the wrist (14cm). Mean values for latency, amplitude, and duration were obtained, and palm/wrist ratios were calculated. Fifteen patients with CTS and 6 with underlying peripheral neuropathy were studied. This technique is useful for diagnosing early CTS and also for identifying an underlying mild peripheral neuropathy, eg, in diabetes mellitus.

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