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Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments.
Sci Adv
January 2025
Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Several human disorders, including Alzheimer's disease (AD), are characterized by the aberrant formation of amyloid fibrils. In many cases, the amyloid core is flanked by disordered regions, known as fuzzy coat. The structural properties of fuzzy coats, and their interactions with their environments, however, have not been fully described to date.
View Article and Find Full Text PDFCoats disease presenting with vitreous hemorrhage and neovascular glaucoma.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, 60612, USA.
Purpose: To describe a patient with Coats disease with an atypical presentation of neovascular glaucoma and vitreous hemorrhage.
Observations: A 15-year-old male presented with five days of pain, redness, and swelling and was found to have neovascular glaucoma in his right eye. Further evaluation revealed Coats disease stage 3AI with a subtotal exudative retinal detachment inferiorly, telangiectatic vessels, and vitreous hemorrhage.
Prevalence of bovine trypanosomosis and tsetse fly density in the Yem special district: a cross-sectional study.
Front Vet Sci
December 2024
Bedele District Livestock Development and Health Office, Bedele, Ethiopia.
This study assesses the prevalence of bovine trypanosomes and the density of tsetse flies in the Yem Special District, Southern Ethiopia, highlighting the disease's significant impact on livestock health and agricultural productivity. Conducted between May 2022 and January 2023, the cross-sectional survey analyzed 960 blood samples for trypanosomes prevalence and tsetse fly density. Results revealed a 10.
View Article and Find Full Text PDFCoats' disease in adulthood with preserved vision after intravitreal aflibercept injection combined with laser photocoagulation : a case report.
BMC Ophthalmol
January 2025
Vitreoretinal Surgery Department, Hugo Chavez Hospital, Turmus Ayya, State of Palestine.
Background: This case report describes a rare case of Coats disease in adult female patient with preserved vision after intravitreal Aflibercept injection and laser photocoagulation.
Case Presentation: A female patient of Asian Palestinian descent, aged 20, exhibited a progressive and painless deterioration in the vision of her left eye over a period of two weeks. She exhibited no additional ocular symptoms.
12-year cumulative incidence rate of rare retinal diseases: a nationwide study in Korea.
Eye (Lond)
January 2025
Department of Ophthalmology, Chung-Ang University, College of Medicine, Seoul, South Korea.
Purpose: Understanding the incidence of rare diseases is important in establishing a proper public health care system and setting target diseases in medical research. Herein, we report the 12-year cumulative incidence of seven rare ocular diseases of the retina in South Korea.
Methods: We analysed clinical records of 1,126,250 South Korean population during 2006~2019.
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