The anti-thrombotic effect of acetyl salicylic acid (ASA) was studied using the following experimental model: a silk thread was inserted in an extracorporeal shunt between the right carotid artery and the opposite jugular vein. A thrombus developed around the thread which was weighed at 10 minutes intervals. ASA inhibits the development of the thrombus at a dose of 3.1 mg/kg. When the dose was increased the anti-thrombotic effect disappeared. These results suggest that ASA may be an effective antithrombotic agent in man if the dosage is based on pharmacological data.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0049-3848(83)90043-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of acetylsalicylic acid on perioperative bleeding complications in deceased donor kidney transplantation.
World J Urol
January 2025
Department of Urology, Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Purpose: The objective of this study was to evaluate the perioperative outcomes and complications associated with the use of acetylsalicylic acid (ASA) in deceased donor kidney transplantation (KTX), with a particular focus on bleeding events.
Methods: We retrospectively analyzed 157 kidney transplant recipients (KTRs) who underwent KTX at Charité Berlin, Department for Urology, between February 2014 and December 2017. Patients were divided into two groups: patients with ASA in their preoperative medication (Group A, n = 59) and patients without ASA use (Group B, n = 98).
Anacardic Acid Derivatives Isolated from Fungal Species as New Histone Acetyltransferase Inhibitors.
Biol Pharm Bull
December 2024
Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
Anacardic acid (AA) was first detected in the shells of cashew nuts, Anacardium occidentale, and is known to possess inhibitory activity against acetyltransferases. Recently, several anacardic acid derivatives (AAds) were isolated from the wild fungus, Tyromyces fissilis, which has been reported as xanthine oxidase inhibitors. In the present study, we investigated whether nine AAds function as acetyltransferase inhibitors.
View Article and Find Full Text PDFImpact of aspirin on the outcome of upper limb AVF placement in hemodialysis patients: Discontinuation or not.
J Vasc Access
December 2024
Department of Vascular and Endovascular Surgery, Imam Hossein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- A study was conducted to evaluate the effects of aspirin on bleeding during arteriovenous fistula (AVF) placement surgery in end-stage renal disease patients, particularly addressing whether discontinuing aspirin is necessary before the surgery.
- The research involved 60 patients, split evenly between those who took 80 mg of aspirin daily and those who did not, with outcomes focusing on blood loss and AVF success.
- Results showed no significant differences in bleeding, operation duration, or AVF outcomes between the two groups, suggesting that patients can continue aspirin use without adverse effects during the surgery, while further research is encouraged.
A randomized trial of antithrombotic therapy in patients with acute coronary syndrome and coronary ectasia.
Am Heart J
November 2024
From the Cardiovascular Critical Care Unit, National Institute of Cardiology Ignacio Chávez, Mexico City, México. Electronic address:
Background: Coronary artery ectasia (CAE) of the culprit infarct artery is a rare finding in patients with acute coronary syndrome (ACS). While anticoagulants have been suggested to reduce recurrent events, the optimal antithrombotic therapy remains unclear.
Methods: OVER-TIME was an open label, exploratory, randomized controlled trial comparing dual antiplatelet therapy (DAPT; acetyl-salicylic-acid 100mg plus clopidogrel 75mg daily) versus single antiplatelet (SAPT, clopidogrel 75mg) plus DOAC (rivaroxaban 15mg) in patients with ACS and CAE.
Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial.
PLoS One
November 2024
Applied Biological Laboratories Inc, New York, NY, United States of America.
Common cold viruses are leading triggers of asthma attacks, causing nearly two million hospitalizations per year and productivity losses approaching $40B. They also increase susceptibility to bacterial infections driving antibiotic use. Post-market clinical studies have questioned the efficacy of most over the counter (OTC) cough and cold ingredients against placebo in treating various symptoms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!