Twenty six cases of cerebellar hemorrhages were reviewed and analyzed. Two patients were comatose on admission and showed clinical evidence of brainstem compression; they were successfully revived after evacuation of the hematomas. This was in contrast with six other comatose patients who did not have evacuation and subsequently died within 48 hours. The other eight cases of so-called benign cerebellar hemorrhage ran a more benign course and recovered without any operative procedures. It is suggested that prompt diagnosis with computed tomography, even in comatose patients, and immediate removal of the hematoma in this group, might result in a better prognosis with this highly lethal condition.
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http://dx.doi.org/10.1016/0090-3019(83)90135-0 | DOI Listing |
Alzheimers Dement
December 2024
Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Background: Data-driven disease progression models of Alzheimer's disease (AD) have identified subtypes in regional patterns of Aβ deposition using amyloid PET. In addition to Aβ accumulation, early frame measures of tracer delivery from amyloid PET are strongly correlated with blood flow. This work explores whether combining tracer delivery with amyloid binding measures can improve the subtype and stage characterisation over amyloid binding alone.
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December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Insulin resistance (IR) is associated with abnormal tau-phosphorylation and IR markers in AD brain co-localize with neurofibrillary tangles. One strategy to overcome brain IR is to increase brain insulin is via intranasal insulin (INI) administration using specialized intranasal devices that deliver insulin to the brain. Our recent INI vs.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Urmia University of Medical Science, Urmia, West Azarbayjan, Iran (Islamic Republic of).
Background: Cerebral microbleeds (CMBs) are small, round aggregations of hemosiderin-laden macrophages that indicate leakage of blood products from cerebral vessels damaged by β-amyloid-40 (Aβ), which is the basis of cerebral amyloid angiopathy (CAA). Pathology studies have demonstrated a high correlation between CAA and AD, both amyloid-related pathologies. CMBs can be visualized commonly using T2*-weighted MRI, as small foci of decreased signal intensity.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Synaptic loss is a key feature of Alzheimer's disease (AD) dementia. In the entorhinal cortex (ERC) and hippocampus, phosphorylated tau (pTau) colocalizes with synaptosomes, and its presence may play a role in AD-related synaptic loss. However, the relationship between pTau and synaptic density is not well understood.
View Article and Find Full Text PDFBackground: Increased body mass index (BMI) in mid-life is associated with a higher risk of Alzheimer's disease (AD). Neurofibrillary tangles (NFTs), comprised of hyperphosphorylated aggregated tau protein, are the pathological hallmark of neurodegenerative tauopathies including Alzheimer's Disease (AD). The relationship between sex-dependent adiposity in late adulthood and tau NFT pathology remain inconclusive.
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