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Background: This video article describes the use of bone-anchored prostheses for patients with transtibial amputations, most often resulting from trauma, infection, or dysvascular disease. Large studies have shown that about half of all patients with a socket-suspended artificial limb experience limited mobility and limited prosthesis use because of socket-related problems. These problems occur at the socket-residual limb interface as a result of a painful and unstable connection, leading to an asymmetrical gait and subsequent pelvic and back pain.

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We describe the case of a 52-year-old man with radiation-induced severe mixed aortic and mitral valve disease, thickening of the aortomitral continuity, mitral annular calcification, and porcelain aorta with limited transcatheter treatment options. By replacing the aorta during circulatory arrest, we demonstrate that it is possible to clamp the ascending aorta to facilitate prosthetic aortic and mitral valve replacement.

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Alzheimer's disease is a disabling neurodegenerative disorder for which no effective treatment currently exists. To predict the diagnosis of Alzheimer's disease could be crucial for patients' outcome, but current Alzheimer's disease biomarkers are invasive, time consuming or expensive. Thus, developing MRI-based computational methods for Alzheimer's disease early diagnosis would be essential to narrow down the phenotypic measures predictive of cognitive decline.

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Lipoblastoma is a rare fatty tumor that can uncommonly arise in the presacral space. When the lesions attain sufficient size, they can cause a multitude of infiltrative and obstructive symptoms. In this report, we present the case of a 1-year-old infant who presented with recurrent urinary retention for 4 months due to a large presacral lipoblastoma, which was successfully resected.

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