The deceleration of the development of young rats during the postnatal ontogenesis under conditions of a low-background chamber (a 10-fold decrease in the natural radiation background) was detected using the criterion of individual growth of the body weight for 10 days of observation. The administration, to the low-background chamber, of uranium salts which restore the natural background (all other experimental conditions being retained) removed the effect observed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

natural background
8
low-background chamber
8
[possible natural
4
background radiation
4
radiation development
4
development mammals]
4
mammals] deceleration
4
deceleration development
4
development young
4
young rats
4

Similar Publications

Background: Sepsis, a critical global health challenge, accounted for approximately 20% of worldwide deaths in 2017. Although the Sequential Organ Failure Assessment (SOFA) score standardizes the diagnosis of organ dysfunction, early sepsis detection remains challenging due to its insidious symptoms. Current diagnostic methods, including clinical assessments and laboratory tests, frequently lack the speed and specificity needed for timely intervention, particularly in vulnerable populations such as older adults, intensive care unit (ICU) patients, and those with compromised immune systems.

View Article and Find Full Text PDF

Background: Judicious utilisation of tertiary care facilities through appropriate risk stratification assumes priority, in a raging pandemic, of the nature of delta variant-predominated second wave of COVID-19 pandemic in India. Prioritisation of tertiary care, through a scientifically validated risk score, would maximise recovery without compromising individual safety, but importantly without straining the health system.

Methods: De-identified data of COVID-19 confirmed patients admitted to a tertiary care hospital in South India, between April 1, 2021 and July 31, 2021, corresponding to the peak of COVID-19 second wave, were analysed after segregating into 'survivors' or 'non-survivors' to evaluate the risk factors for COVID-19 mortality at admission and formulate a risk score with easily obtainable but clinically relevant parameters for accurate patient triaging.

View Article and Find Full Text PDF

In order to understand the spatial distribution, influencing factors, pollution level and sources of heavy metals in black soil profiles in Northeast China, black soil profile samples were collected from five sampling points in Haicheng City, Liaoning Province, with the deepest profile depth of 50m. The contents of heavy metals (As, Cd, Cr, Cu, Hg, Ni, Pb and Zn) in soil at different depths were analyzed, and the distribution characteristics and influencing factors of heavy metals in black soil profiles were analyzed. The pollution level of heavy metals in soil was evaluated based on the geo-accumulation index method and enrichment factor method, and the sources of heavy metals in soil were analyzed based on principal component analysis.

View Article and Find Full Text PDF

A novel model of central precocious puberty disease: Paternal MKRN3 gene-modified rabbit.

Animal Model Exp Med

January 2025

Guangdong Medical Laboratory Animal Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Background: Makorin ring finger protein 3 gene (MKRN3) gene mutation is the most common genetic cause of central precocious puberty (CPP) in children. Due to the lack of ideal MKRN3-modified animal model (MKRN3-modified mice enter puberty only 4-5 days earlier than normal mice), the related research is limited.

Methods: Therefore, the MKRN3-modified rabbit was developed using CRISPR (clustered regularly interspaced short palindromic repeats) gene editing technology.

View Article and Find Full Text PDF

Background: Sepsis and acute respiratory distress syndrome (ARDS) are common inflammatory conditions in intensive care, with ARDS significantly increasing mortality in septic patients. PANoptosis, a newly discovered form of programmed cell death involving multiple cell death pathways, plays a critical role in inflammatory diseases. This study aims to elucidate the PANoptosis-related genes (PRGs) and their involvement in the progression of sepsis to ARDS.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!