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Mesenchymal Stem Cell-conditioned Medium Attenuated CoCl2-induced Injury of Renal Tubular Epithelial Cells by Inhibiting NCOA1, HIF-1α, and Sox9.
Curr Pharm Des
January 2025
Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Backgrounds: Renal interstitial fibrosis (RIF) constitutes the ultimate pathological alteration in nearly all chronic kidney diseases (CKD). Mesenchymal stem cell conditioned medium (MSC-CM) exhibits an alleviating impact on renal fibrosis; however, the underlying mechanism remains unclear. The objective of this study was to explore whether MSC-CM regulates the expression of α-smooth muscle actin (α-SMA), Transforming growth factor-β1 (TGF-β1), Hypoxia-inducible factor-1α (HIF-1α), Nuclear receptor coactivators (NCOA1), and SRY-related high mobility (Sox9).
View Article and Find Full Text PDFEnhanced pathogen identification among patients with clinically suspected meningitis.
S Afr J Infect Dis
December 2024
Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Background: Delayed or incorrect treatment of meningitis may result in adverse patient outcomes. However, laboratory testing in resource-limited settings is often limited to conventional diagnostic methods. We explored the utility of syndromic molecular assays for diagnosis.
View Article and Find Full Text PDFCellular and biochemical alterations induced by diesel oil in the brown alga Sargassum cymosum var. stenophyllum cultured in vitro.
Chemosphere
January 2025
Plant Morphogenesis and Biochemistry Laboratory, Federal University of Santa Catarina, P. O. Box 476, 88049-900, Florianopolis, SC, Brazil. Electronic address:
The effect of the in vitro acute exposure to diesel oil (0.001%, 0.01%, 0.
View Article and Find Full Text PDFAnalysis of neuraminidase activity of human parainfluenza viruses using enzyme-linked lectin assay and BTP3-Neu5Ac assay.
Microbiol Immunol
November 2024
Virus Research Center, Clinical Research Division, Sendai Medical Center, National Hospital Organization, Sendai, Japan.
Human parainfluenza viruses (hPIVs) are causative agents of upper and lower respiratory tract infections and they have four serotypes. The virion surface displays hemagglutinin-neuraminidase (HN), having hemagglutinating (HA) and neuraminidase (NA) activities in a single molecule. The HA activity binds the virion to sialic acid on the viral receptor on host cells and the NA releases the progeny viruses from the cell surface.
View Article and Find Full Text PDFMorphological and cytochemical characterization of the peripheral blood cells in .
Heliyon
September 2024
Lab of Pathology and Immunology of Aquatic Animals, Jiangsu Ocean University, Lianyungang, 222005, China.
The flounder () is a highly nutritious, cultured bony fish with a high economic value. The health of the fish is closely related to its blood cells, which are critical for oxygen transport, natural defense, and immunity. The microstructures, classification, counting and size of peripheral blood cells in .
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