Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01496663 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomimetic Charge-Neutral Anion Receptors for Reversible Binding and Release of Highly Hydrated Phosphate in Water.
Angew Chem Int Ed Engl
August 2024
Key Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 102488, China.
Control of phosphate capture and release is vital in environmental, biological, and pharmaceutical contexts. However, the binding of trivalent phosphate (PO ) in water is exceptionally difficult due to its high hydration energy. Based on the anion coordination chemistry of phosphate, in this study, four charge-neutral tripodal hexaurea receptors (L-L), which were equipped with morpholine and polyethylene glycol terminal groups to enhance their solubility in water, were synthesized to enable the pH-triggered phosphate binding and release in aqueous solutions.
View Article and Find Full Text PDFEvaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Nucleic Acids Res
June 2024
Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA.
Oral delivery is the most widely used and convenient route of administration of medicine. However, oral administration of hydrophilic macromolecules is commonly limited by low intestinal permeability and pre-systemic degradation in the gastrointestinal (GI) tract. Overcoming some of these challenges allowed emergence of oral dosage forms of peptide-based drugs in clinical settings.
View Article and Find Full Text PDFThe chemical characteristics of different sodium iron ethylenediaminetetraacetate sources and their relative bioavailabilities for broilers fed with a conventional corn-soybean meal diet.
J Anim Sci Biotechnol
January 2024
College of Animal Science and Technology, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Background: Our previous studies demonstrated that divalent organic iron (Fe) proteinate sources with higher complexation or chelation strengths as expressed by the greater quotient of formation (Q) values displayed higher Fe bioavailabilities for broilers. Sodium iron ethylenediaminetetraacetate (NaFeEDTA) is a trivalent organic Fe source with the strongest chelating ligand EDTA. However, the bioavailability of Fe when administered as NaFeEDTA in broilers and other agricultural animals remains untested.
View Article and Find Full Text PDFInfluence of soil properties and aging on exogenous antimony toxicity to Caenorhabditis elegans in agricultural soil.
Environ Sci Pollut Res Int
February 2024
School of Geography, Earth & Environmental Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Article Synopsis
- The study investigates how soil affects the aging and toxicity of antimony (Sb) on nematodes, which are important for nitrogen cycling in agriculture.
- Key findings show that nematode reproduction is more sensitive to trivalent antimony (Sb(III)) toxicity than other growth measures, with toxicity increasing significantly over time in contaminated soils.
- The research highlights that soil pH is a major factor influencing the aging of Sb toxicity, suggesting that evaluating Sb risk in soils requires considering both aging processes and specific soil conditions to improve environmental management strategies.
A plasmid containing the human metallothionein-II gene selectively distinguishes trivalent lanthanum from several divalent heavy metal cations during monoclonal antibody-assisted agarose gel electrophoresis.
Toxicol Ind Health
February 2024
Department of Anatomy, Pathology Section, Sam Houston State University, College of Osteopathic Medicine, Conroe, TX, USA.
Trivalent lanthanide ions are known for their ability to interact with calcium-binding sites in various proteins. There is a need to assess the bioavailability of lanthanides and other heavy metals introduced into the body as components of implants or as contrast agents. This study aimed to develop a method to address bioavailability and/or presence of trivalent lanthanide ions by examining electrophoretic mobility in an agarose gel of a plasmid harboring the human metallothionein-II gene ().
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!